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HDAC1 Controls CD8+ T Cell Homeostasis and Antiviral Response
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Journal Article
HDAC1 Controls CD8+ T Cell Homeostasis and Antiviral Response
2014
Overview
Reversible lysine acetylation plays an important role in the regulation of T cell responses. HDAC1 has been shown to control peripheral T helper cells, however the role of HDAC1 in CD8+ T cell function remains elusive. By using conditional gene targeting approaches, we show that LckCre-mediated deletion of HDAC1 led to reduced numbers of thymocytes as well as peripheral T cells, and to an increased fraction of CD8+CD4- cells within the CD3/TCRβlo population, indicating that HDAC1 is essential for the efficient progression of immature CD8+CD4- cells to the DP stage. Moreover, CD44hi effector CD8+ T cells were enhanced in mice with a T cell-specific deletion of HDAC1 under homeostatic conditions and HDAC1-deficient CD44hi CD8+ T cells produced more IFNγ upon ex vivo PMA/ionomycin stimulation in comparison to wild-type cells. Naïve (CD44l°CD62L+) HDAC1-null CD8+ T cells displayed a normal proliferative response, produced similar amounts of IL-2 and TNFα, slightly enhanced amounts of IFNγ, and their in vivo cytotoxicity was normal in the absence of HDAC1. However, T cell-specific loss of HDAC1 led to a reduced anti-viral CD8+ T cell response upon LCMV infection and impaired expansion of virus-specific CD8+ T cells. Taken together, our data indicate that HDAC1 is required for the efficient generation of thymocytes and peripheral T cells, for proper CD8+ T cell homeostasis and for an efficient in vivo expansion and activation of CD8+ T cells in response to LCMV infection.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Antiviral Agents - pharmacology
/ Antiviral Agents - therapeutic use
/ CD8-Positive T-Lymphocytes - drug effects
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - metabolism
/ Ethics
/ Histone Deacetylase 1 - metabolism
/ Hyaluronan Receptors - metabolism
/ Interferon-gamma - metabolism
/ Lymphocytic Choriomeningitis - drug therapy
/ Lymphocytic Choriomeningitis - immunology
/ Lysine
/ Mice
/ Proteins
/ Rodents
/ Toxicity
/ Tumor Necrosis Factor-alpha - metabolism
/ Viruses
