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A Murine, Bispecific Monoclonal Antibody Simultaneously Recognizing β-Glucan and MP65 Determinants in Candida Species
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A Murine, Bispecific Monoclonal Antibody Simultaneously Recognizing β-Glucan and MP65 Determinants in Candida Species
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Journal Article
A Murine, Bispecific Monoclonal Antibody Simultaneously Recognizing β-Glucan and MP65 Determinants in Candida Species
2016
Overview
There is a real medical need of new diagnostic tools for the early recognition of invasive Candida infections. We exploited a rather simple and rapid redox methodology to construct a bispecific monoclonal antibody (bsmAb) that combines a monoclonal antibody (mAb) directed against 1,3-β-D-glucan, a well-known, pan-fungal diagnostic biomarker, with a mAb recognizing MP65, a major immunogenic mannoprotein secreted by C.albicans and other Candida species. The bsmAb (MP65/bglu mAb) was successfully produced and purified at high yields and proved to bind and reveal simultaneously, with high sensitivity, the β-glucan and MP65 antigens in both purified and native forms. The MP65/bglu mAb is the first bispecific antibody generated against a fungal microorganism and may prove useful for the concurrent detection of different and clinically significant Candida biomarkers in patient sera.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Antibodies, Bispecific - immunology
/ Antibodies, Fungal - immunology
/ Antibodies, Monoclonal - immunology
/ Antigens
/ Antigens, Fungal - immunology
/ Candida
/ Candida albicans - immunology
/ Candidiasis, Invasive - blood
/ Candidiasis, Invasive - diagnosis
/ Candidiasis, Invasive - immunology
/ Fungal Proteins - immunology
/ Fungi
/ Glucan
/ Humans
/ Immunodominant Epitopes - blood
/ Immunodominant Epitopes - immunology
/ Medicine and Health Sciences
/ Membrane Glycoproteins - blood
/ Membrane Glycoproteins - immunology
/ Mice
/ Research and Analysis Methods
/ Sodium
/ β-Glucan
