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Spatial and temporal patterns of Lyme Neuroborreliosis on Funen, Denmark from 1995–2014
by
Knudtzen, Fredrikke Christie
, Bødker, Rene
, Andreasen, Amalie Muus
, Skarphedinsson, Sigurdur
, Dehlendorff, Petter Bart
, Kjær, Lene Jung
in
692/699/375/1367
/ 692/700/478/174
/ Animal populations
/ Arachnids
/ Borrelia burgdorferi
/ Borreliosis
/ Cluster Analysis
/ Denmark - epidemiology
/ Disease
/ Disease hot spots
/ Epidemiology
/ Geographical distribution
/ Geography, Medical
/ Health surveillance
/ History, 21st Century
/ Humanities and Social Sciences
/ Humans
/ Incidence
/ Lyme disease
/ Lyme Neuroborreliosis - epidemiology
/ Lyme Neuroborreliosis - history
/ Lyme Neuroborreliosis - microbiology
/ multidisciplinary
/ Public Health Surveillance
/ Science
/ Science (multidisciplinary)
/ Seasonal distribution
/ Seasonal variations
/ Seasons
/ Spatio-Temporal Analysis
/ Spirochetes
2020
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Spatial and temporal patterns of Lyme Neuroborreliosis on Funen, Denmark from 1995–2014
by
Knudtzen, Fredrikke Christie
, Bødker, Rene
, Andreasen, Amalie Muus
, Skarphedinsson, Sigurdur
, Dehlendorff, Petter Bart
, Kjær, Lene Jung
in
692/699/375/1367
/ 692/700/478/174
/ Animal populations
/ Arachnids
/ Borrelia burgdorferi
/ Borreliosis
/ Cluster Analysis
/ Denmark - epidemiology
/ Disease
/ Disease hot spots
/ Epidemiology
/ Geographical distribution
/ Geography, Medical
/ Health surveillance
/ History, 21st Century
/ Humanities and Social Sciences
/ Humans
/ Incidence
/ Lyme disease
/ Lyme Neuroborreliosis - epidemiology
/ Lyme Neuroborreliosis - history
/ Lyme Neuroborreliosis - microbiology
/ multidisciplinary
/ Public Health Surveillance
/ Science
/ Science (multidisciplinary)
/ Seasonal distribution
/ Seasonal variations
/ Seasons
/ Spatio-Temporal Analysis
/ Spirochetes
2020
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Spatial and temporal patterns of Lyme Neuroborreliosis on Funen, Denmark from 1995–2014
by
Knudtzen, Fredrikke Christie
, Bødker, Rene
, Andreasen, Amalie Muus
, Skarphedinsson, Sigurdur
, Dehlendorff, Petter Bart
, Kjær, Lene Jung
in
692/699/375/1367
/ 692/700/478/174
/ Animal populations
/ Arachnids
/ Borrelia burgdorferi
/ Borreliosis
/ Cluster Analysis
/ Denmark - epidemiology
/ Disease
/ Disease hot spots
/ Epidemiology
/ Geographical distribution
/ Geography, Medical
/ Health surveillance
/ History, 21st Century
/ Humanities and Social Sciences
/ Humans
/ Incidence
/ Lyme disease
/ Lyme Neuroborreliosis - epidemiology
/ Lyme Neuroborreliosis - history
/ Lyme Neuroborreliosis - microbiology
/ multidisciplinary
/ Public Health Surveillance
/ Science
/ Science (multidisciplinary)
/ Seasonal distribution
/ Seasonal variations
/ Seasons
/ Spatio-Temporal Analysis
/ Spirochetes
2020
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Spatial and temporal patterns of Lyme Neuroborreliosis on Funen, Denmark from 1995–2014
Journal Article
Spatial and temporal patterns of Lyme Neuroborreliosis on Funen, Denmark from 1995–2014
2020
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Overview
In Europe, Lyme neuroborreliosis (LNB) is the most severe manifestation of Lyme borreliosis and has recently been added to the communicable disease surveillance list for EU/EEA by the European Commission. In Northern Europe, LNB is primarily caused by the spirochete
Borrelia garinii
and transmitted by the tick
Ixodes ricinus
. This Danish observational epidemiologic case-control study includes every identified LNB patient (n = 401) on Funen, Denmark, from 1995-2014. We display spatial and temporal LNB incidence variation, seasonal distribution of cases and local spatial case clustering. Seasonal patterns show LNB symptom-onset peaking in July and a significant seasonal difference in number of cases (p < 0.01). We found no significant change in seasonality patterns over time when dividing the study period into 5-year intervals. We identified a significant local geographical hot-spot of cases with a relative risk of 2.44 (p = 0.013). Analysis revealed a significantly shorter distance to nearest forest for cases compared with controls (p < 0.001). We present a novel map of the focal geographical distribution of LNB cases in a high endemic borreliosis area. Continued studies of case clustering in the epidemiology of LNB are of key importance in guiding intervention strategies.
Publisher
Nature Publishing Group UK,Nature Publishing Group
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