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Evidence for a large-scale brain system supporting allostasis and interoception in humans
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Evidence for a large-scale brain system supporting allostasis and interoception in humans
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Evidence for a large-scale brain system supporting allostasis and interoception in humans
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Journal Article
Evidence for a large-scale brain system supporting allostasis and interoception in humans
2017
Overview
Large-scale intrinsic brain systems have been identified for exteroceptive senses (such as sight, hearing and touch). We introduce an analogous system for representing sensations from within the body, called interoception, and demonstrate its relation to regulating peripheral systems in the body, called allostasis. Employing the recently introduced Embodied Predictive Interoception Coding (EPIC) model, we used tract-tracing studies of macaque monkeys, followed by two intrinsic functional magnetic resonance imaging samples (
N
= 280 and
N
= 270) to evaluate the existence of an intrinsic allostatic–interoceptive system in the human brain. Another sample (
N
= 41) allowed us to evaluate the convergent validity of the hypothesized allostatic–interoceptive system by showing that individuals with stronger connectivity between system hubs performed better on an implicit index of interoceptive ability related to autonomic fluctuations. Implications include insights for the brain’s functional architecture, dissolving the artificial boundary between mind and body, and unifying mental and physical illness.
Kleckner
et al.
use monkey and human data to identify an intrinsic brain system that supports interoception (that is, sensations from within the body) and allostasis (that is, the process by which the brain maintains energy regulation in the body).
Publisher
Nature Publishing Group UK,Nature Publishing Group
