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Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia

by Drexler, Helmut , Schaper, Wolfgang , Napp, L Christian , Limbourg, Anne , Korff, Thomas , Limbourg, Florian P

in Analytical Chemistry / Angiogenesis / Animals / Biological Techniques / Biomedical and Life Sciences / Blood vessels / Cardiovascular diseases / Computational Biology/Bioinformatics / Development and progression / Disease Models, Animal / Experimental design / Femoral Artery - growth & development / Femoral Artery - pathology / Femoral Artery - surgery / Foot - blood supply / Foot - pathology / Ischemia / Ischemia - physiopathology / Laser-Doppler Flowmetry / Lasers / Life Sciences / Lower Extremity - blood supply / Lower Extremity - pathology / Male / Mice / Microarrays / Muscles / Neovascularization / Neovascularization, Pathologic / Organic Chemistry / Perfusion Imaging - methods / Physiological aspects / Physiology / Protocol / Risk factors

2009

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Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia

by Drexler, Helmut , Schaper, Wolfgang , Napp, L Christian , Limbourg, Anne , Korff, Thomas , Limbourg, Florian P

2009

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Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia

by Drexler, Helmut , Schaper, Wolfgang , Napp, L Christian , Limbourg, Anne , Korff, Thomas , Limbourg, Florian P

2009

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Journal Article

Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia

Drexler, Helmut,

Schaper, Wolfgang,

Napp, L Christian,

Limbourg, Anne,

Korff, Thomas,

Limbourg, Florian P

2009

Overview

Blood vessel growth in adult organisms involves the following two fundamental processes: angiogenesis, the proliferation and extension of capillary networks; and arteriogenesis, the growth of functional arteries. We provide a protocol for the evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Surgical ligation of the femoral artery at a specific site triggers arteriogenesis of small, pre-existing collateral arteries into functional conduit vessels proximally and ischemic angiogenesis distally. The vascular response to hind-limb ischemia can be readily evaluated by laser Doppler-based perfusion measurements, histological quantification of arteriogenesis and angiogenesis or whole-mount visualization of arteries in limb muscles. Depending on the experimental design, the protocol takes between 4 and 29 d to complete; however, the net working time is about 2 d per mouse. The concurrent and specific analysis of postnatal angiogenesis and arteriogenesis in the same animal is a unique feature of the protocol.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

Analytical Chemistry

/ Angiogenesis

/ Animals

/ Biological Techniques

/ Biomedical and Life Sciences

/ Blood vessels

/ Cardiovascular diseases