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Ex vivo culture of human prostate tissue and drug development
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Journal Article
Ex vivo culture of human prostate tissue and drug development
2013
Overview
In this Perspectives article, Centenera
et al
. chronicle the development of
ex vivo
culture models that utilize tumour material from men with prostate cancer and discuss the advantages, limitations, and potential applications of these systems to expedite the evaluation of novel drugs for the treatment of prostate cancer.
Although an array of new therapeutics exist for prostate cancer, the development of agents that can improve outcomes for men with prostate cancer remains inefficient, costly, and frustratingly slow. A major impediment to the clinical translation of research findings is the lack of preclinical models that can accurately predict the clinical efficacy of new drugs and, therefore, enable the selection of agents that are most suitable for clinical trials. An approach that is gaining popularity in the prostate cancer community is
ex vivo
culture of primary human tissues, which retains the native tissue architecture, hormone responsiveness, and cell-to-cell signalling of the tumour microenvironment in a dynamic and manipulable state.
Ex vivo
culture systems recapitulate the structural complexity and heterogeneity of human prostate cancers in a laboratory setting, making them an important adjunct to current cell-line-based and animal-based models. When incorporated into preclinical studies,
ex vivo
cultured tissues enable robust quantitative evaluation of clinically relevant end points representing drug efficacy, investigation of therapy resistance, and biomarker discovery. By providing new clinically relevant insights into prostate carcinogenesis, it is likely that
ex vivo
culture will enhance drug development programmes and improve the translational 'hit rate' for prostate cancer research.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - pharmacology
/ Antineoplastic Agents - therapeutic use
/ Cancer
/ Drug Resistance, Neoplasm - drug effects
/ Drug Resistance, Neoplasm - physiology
/ Drugs
/ Humans
/ Male
/ Medicine
/ Prostatic Neoplasms - drug therapy
/ Prostatic Neoplasms - pathology
/ Success
/ Tumor Microenvironment - drug effects
/ Tumor Microenvironment - physiology
/ Tumors
/ Urology
