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Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure
Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure
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Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure
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Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure
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Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure
Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure
Journal Article

Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure

2001
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Overview
Mechanical left ventricular assist devices have been used as a bridge to cardiac transplantation, but not as long-term therapy. In this study of patients with severe heart failure who were not candidates for transplantation, left ventricular assist was compared with optimal medical therapy. The one-year survival rate was 52 percent in the device group and 25 percent in the medical-therapy group. The device permitted patients to be ambulatory and improved the quality of life. In this study of patients with severe heart failure who were not candidates for transplantation, left ventricular assist was compared with optimal medical therapy. This study is an important step in the further development of artificial-heart technology. Improving the survival and the quality of life of patients with end-stage heart failure has been the underlying goal of decades of research on mechanical circulatory-support devices. This effort was stimulated by the increasing prevalence of this disorder and its grave prognosis. Heart failure affects an estimated 4.7 million Americans, with 550,000 new cases diagnosed annually and annual cost estimates ranging from $10 billion to $40 billion. 1 , 2 The aggregate five-year survival rate of patients with heart failure is approximately 50 percent, 1 whereas the one-year mortality rate of those with advanced disease may exceed 50 percent. 3 Patients with mild-to-moderate heart . . .