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A Wearable In‐Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood
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A Wearable In‐Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood
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Journal Article
A Wearable In‐Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood
2025
Overview
The pain‐free monitoring of blood‐based biomarkers is essential for early detection of diseases like cancers, infections, and metabolic disorders such as diabetes. While research often focuses on venous blood analysis, menstruation blood is an overlooked but promising source. Evidence shows a strong correlation between biomarker levels in menstruation and venous blood for many clinical analytes. A wearable, microfluidic monitoring platform integrated into hygiene pads is presented for electronic‐free, naked‐eye detection of disease biomarkers in menstruation blood (MenstruAI). Semi‐quantitative detection of C‐reactive protein (CRP), cancer biomarkers carcinoembryonic antigen (CEA) and cancer antigen 125 (CA‐125), and endometriosis biomarker CA‐125 is demonstrated. The biomarker‐induced color changes can be read by the naked eye or a smartphone app with a machine‐learning algorithm for semi‐quantitative analysis. MenstruAI can revolutionize women's health by offering a non‐invasive, affordable, and accessible health monitoring method, democratizing healthcare, and enhancing service availability and equity. MenstruAI integrates a paper‐based biosensor into sanitary pads to detect biomarkers in menstrual blood, enabling accessible, lab‐free diagnostics health. The platform supports early disease detection, especially in underserved communities, while challenging menstrual stigma and opening pathways for scalable, inclusive, and sustainable population health screening through wearable technologies.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
