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Investigation of mumps vaccine failures in Minsk, Belarus, 2001–2003

by Atrasheuskaya, Alina , Karpov, Igor A. , Ignatyev, George M. , Blatun, Elena M. , Rubin, Steven , Kulak, Michail V. , Atrasheuskaya, Alena V.

in Adolescent / Adult / Age / Allergy and Immunology / Antibodies, Viral - blood / Antigens, Viral - immunology / Base Sequence / Belarus / Failure / Female / Genotype / Hospitals / Humans / Immunoglobulin G - blood / Infectious diseases / Male / Molecular Sequence Data / Mumps / Mumps - immunology / Mumps - virology / Mumps genotyping / Mumps Vaccine - immunology / Mumps virus / Mumps virus - classification / Mumps virus - genetics / Mumps virus - immunology / Mumps virus - isolation & purification / Neutralization Tests / Patients / Phylogeny / Population / Republic of Belarus / RNA, Viral - genetics / Sequence Analysis, DNA / Serologic Tests / Serotyping / Vaccine failure / Vaccines

2007

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Investigation of mumps vaccine failures in Minsk, Belarus, 2001–2003

by Atrasheuskaya, Alina , Karpov, Igor A. , Ignatyev, George M. , Blatun, Elena M. , Rubin, Steven , Kulak, Michail V. , Atrasheuskaya, Alena V.

2007

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Investigation of mumps vaccine failures in Minsk, Belarus, 2001–2003

by Atrasheuskaya, Alina , Karpov, Igor A. , Ignatyev, George M. , Blatun, Elena M. , Rubin, Steven , Kulak, Michail V. , Atrasheuskaya, Alena V.

2007

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Journal Article

Investigation of mumps vaccine failures in Minsk, Belarus, 2001–2003

Atrasheuskaya, Alina,

Karpov, Igor A.,

Ignatyev, George M.,

Blatun, Elena M.,

Rubin, Steven,

Kulak, Michail V.,

Atrasheuskaya, Alena V.

2007

Overview

The purpose of this study was to investigate mumps vaccine failures (VF) in a highly vaccinated population of Minsk, Belarus, and to investigate a possible role for virus strain-specific immunity. During our 3-year study period, 22 adults were admitted to the Infectious Diseases Hospital in Minsk with a diagnosis of mumps. A genotype H1 mumps virus (MuV) strain was identified in all patients. Of 15 patients from whom the paired sera were collected, 9 were confirmed to have been previously vaccinated. Serological examinations indicated primary VF in seven of these cases and secondary VF in two. Despite almost all vaccinated patients possessing MuV specific IgG, few possessed neutralizing antibody to the vaccine strain and titers were nominal. Importantly, none of the sera were able to neutralize a genotype H MuV strain. Our results demonstrate the importance of assaying for neutralizing antibody and support the assertion that antigenic differences between wild type and vaccine MuV strains may play a role in cases of breakthrough infection in vaccinees.

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Publisher

Elsevier Ltd,Elsevier Limited

Subject

Adolescent

/ Adult

/ Age

/ Allergy and Immunology

/ Antibodies, Viral - blood

/ Antigens, Viral - immunology

/ Base Sequence