Journal Article

Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

Muñoz, Miguel Ángel, Ortega-Calvo, M., Álvarez-Pérez, Jacqueline, Toledo, Estefanía, Martínez, Jose Alfredo, Vázquez, Clotilde, Vidal, Josep, Tur, Josep A., García-Rios, Antonio, Daimiel, Lidia, Matía, Pilar, Estruch, Ramón, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Fitó, Montserrat, Izquierdo, Marisol, Pintó, Xavier, Zomeño, Maria Dolores, Ruíz-Canela, Miguel, Vioque, Jesús, Corella, Dolores, López-Miranda, José, Pérez-López, Jessica, Abete, Itziar, Arós, Fernando, García de la Hera, Manoli, Ortega-Azorín, Carolina, Martín, Vicente, Bueno-Cavanillas, Aurora, Tinahones, Francisco J., Salas-Salvadó, Jordi, Serra-Majem, Lluis, Delgado-Rodríguez, Miguel, Romaguera, Dora, Ros, Emilio, Lecea, Oscar, Sánchez-Villegas, Almudena, Babio, Nancy

2018

Overview

Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63–0.94), 0.71 (0.58–0.87), and 0.78 (0.64–0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5–1 g/day) was significantly associated with a lower prevalence of depression. Conclusion: In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.

• Publisher: MDPI AG,MDPI
• Subject: Aged / Animals / antidepressants / Body mass index / confidence interval / Cross-Sectional Studies / Depression - epidemiology / Depression - prevention & control / Depressive Disorder - epidemiology / Depressive Disorder - prevention & control / Diabetes / Diet / Diet Surveys / Drug dosages / Endocrinology / Energy / Energy Intake / Epidemiology / Fatty acids / Fatty Acids, Omega-3 - administration & dosage / Fatty Acids, Omega-3 - therapeutic use / fatty fish / Feeding Behavior / Female / Fishes / Food / food frequency questionnaires / Health care / Health sciences / Hospitals / Humans / Hypertension / Internal medicine / Leisure / Logistic Models / Male / Medical diagnosis / Mental depression / Metabolism / Middle Aged / Nutrition research / Odds Ratio / Omega-3 fatty acids / Polyunsaturated fatty acids / Prevalence / Preventive medicine / Public health / Questionnaires / regression analysis / Research centers / Seafood / seafood consumption / seafoods / Surveys and Questionnaires / Vegetable oils / Womens health