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Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule

by Chang, Wenjun , Wang, Xiachang , Yuan, Jingzhe , Yang, Li , Wu, Fei , Dai, Haofu , Zeng, Yanbo , Gai, Cuijuan , Peng, Hanyang , Zhang, Rui

in Absolute configuration / Alcyonacea / Animals / Anthozoa - chemistry / anti-inflammatory activity / Carbon / cembranoid diterpene / China / Circular Dichroism / Coral reefs / Corals / Crystallography / Crystallography, X-Ray / Density functional theory / Dichroism / Diterpenes / Diterpenes - chemistry / Diterpenes - isolation & purification / Diterpenes - pharmacology / Lead compounds / Lipopolysaccharides / Lipopolysaccharides - pharmacology / Magnetic Resonance Spectroscopy / Metabolites / Mice / Molecular Structure / Natural products / Nitric oxide / Nitric Oxide - metabolism / NMR / Nuclear magnetic resonance / Plant metabolites / Quantum mechanics / R&D / RAW 264.7 Cells / Research & development / Sarcophyton / Secondary metabolites / Single crystals / soft coral / structural elucidation / X-ray crystallography

2024

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Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule

by Chang, Wenjun , Wang, Xiachang , Yuan, Jingzhe , Yang, Li , Wu, Fei , Dai, Haofu , Zeng, Yanbo , Gai, Cuijuan , Peng, Hanyang , Zhang, Rui

2024

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Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule

by Chang, Wenjun , Wang, Xiachang , Yuan, Jingzhe , Yang, Li , Wu, Fei , Dai, Haofu , Zeng, Yanbo , Gai, Cuijuan , Peng, Hanyang , Zhang, Rui

2024

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Journal Article

Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule

Chang, Wenjun,

Wang, Xiachang,

Yuan, Jingzhe,

Yang, Li,

Wu, Fei,

Dai, Haofu,

Zeng, Yanbo,

Gai, Cuijuan,

Peng, Hanyang,

Zhang, Rui

2024

Overview

Cembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A–E (1–5), were isolated from the soft coral Sarcophyton crassocaule, along with five previously reported compounds (6–10). The structures and absolute configuration for new compounds 1–5 were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations. Compounds 3, 4, and 9 showed moderate inhibition of nitric oxide generation in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Overall, our research results have enriched the library of secondary metabolites from soft corals, providing more molecular entities for subsequent research and development of related compounds.

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Publisher

MDPI AG,MDPI

Subject

Absolute configuration

/ Alcyonacea

/ Animals

/ Anthozoa - chemistry

/ anti-inflammatory activity

/ Carbon

/ cembranoid diterpene