Journal Article

A cross-sectional study of acute cor pulmonale in acute respiratory distress syndrome patients in China

Zhu, Ran, Zhang, Hong-Min, Wang, Xiao-Ting, Yu, Rong-Guo, Su, Long-Xiang, Pan, Pan, Liu, Da-Wei, Shang, Xiu-Ling, He, Wei, Zhang, Li-Na

2019

Overview

Increased right ventricle afterload during acute respiratory distress syndrome (ARDS) may induce acute cor pulmonale (ACP), which is associated with a poor clinical outcome. Echocardiography is now considered as a rapid and non-invasive tool for diagnosis of ACP. The aims of this study were to investigate the morbidity and mortality rates of ACP in ARDS patients in intensive care units (ICUs) across the mainland of China and to determine the severity and prognosis of ACP in ARDS patients through an ultrasound protocol (TRIP). And the association between ACP related factors and the ICU mortality will be revealed. This study is a multicenter and cross-sectional study in China which will include ICU participants when diagnosed as ARDS. The ultrasound protocol, known as the TRIP, is proposed as severity assessment for ACP, which includes tricuspid regurgitation velocity (T), right ventricular size (R), inferior vena cava diameter fluctuation (I), and pulmonary regurgitation velocity (P). The 28-day mortality, ICU/hospital mortality, the length of stay in ICU, mechanical ventilation days, hemodynamic parameters and lab parameters of liver function and kidney function are all recorded. This large-scale study would give a sufficient epidemic investigation of ACP in ARDS patients in China. In addition, with the TRIP protocol, we expect that we could stratify ACP with more echocardiography parameters. NCT03827863, https://clinicaltrials.gov/ct2/show/NCT03827863.

• Publisher: Lippincott Williams & Wilkins Ovid Technologies,Department of Critical Care Medicine,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China%Department of Critical Care Medicine,Fujian Provincial Hospital,Fujian Provincial Center for Critical Care Medicine,Fujian Medical University,Fuzhou,Fujian 350001,China%Department of Critical Care Medicine,The First Hospital of China Medical University,Shenyang,Liaoning 110001,China%Department of Critical Care Medicine,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China%Department of Respiratory and Critical Care Medicine,Chinese PLA General Hospital,Beijing 100853,China%Department of Critical Care Medicine,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China,Wolters Kluwer Health,Wolters Kluwer
• Subject: Blood / China / Chronic obstructive pulmonary disease / Consent / Cor pulmonale / Cross-Sectional Studies / Edema / Flow velocity / Heart / Humans / Intensive care / Intensive Care Units - statistics & numerical data / Morbidity / Mortality / Patients / Pulmonary arteries / Pulmonary Heart Disease - pathology / Pulmonary hypertension / Respiration, Artificial / Respiratory distress syndrome / Respiratory Distress Syndrome - pathology / Study Protocol / Ultrasonic imaging / Ventilators