Journal Article

Usefulness of Early Treatment With Melatonin to Reduce Infarct Size in Patients With ST-Segment Elevation Myocardial Infarction Receiving Percutaneous Coronary Intervention (From the Melatonin Adjunct in the Acute Myocardial Infarction Treated With Angioplasty Trial)

Belleyo-Belkasem, Carima, Giménez Poderós, Teresa, Bosa-Ojeda, Francisco, Nazco-Casariego, Julia, Bethencourt, Miguel, Leiva, Miguel, Garcia-Camarero, Tamara, Yanes-Bowden, Geoffrey, Juarez-Prera, Ruben, Lara-Padrón, Antonio, Mendez-Vargas, Corabel, Lacalzada-Almeida, Juan, Dominguez-Rodriguez, Alberto, Abreu-Gonzalez, Pedro, de la Torre-Hernandez, Jose M., Laynez-Cerdeña, Ignacio, Sanchez-Grande, Alejandro, Diaz-Flores, Lucio, Aldea-Perona, Ana, Marí-Lopez, Belen, Izquierdo, Mariela, Caballero-Estevez, Natalia, Perez-Jorge, Pablo, Reiter, Russel J., Ferrer-Hita, Julio, Padilla, Marta, Consuegra-Sanchez, Luciano, Barragan-Acea, Antonio, Gonzalez, Esther, Soria-Arcos, Federico, Piccolo, Raffaele, Gonzalez-Gonzalez, Julia, Blanco-Palacios, Gabriela, Virgos-Aller, Tirso, del Mar Garcia-Saiz, Maria, Martin-Cabeza, Marta, Duque, Amelia, Barrios, Patricia, Betancor, Ivan, Miranda, Julio, de la Rosa, Alejandro, Vargas-Torres, Manuel, Lopez, Jorge, Martinez, Lourdes

2017

Overview

Melatonin, an endogenously produced hormone, might potentially limit the ischemia reperfusion injury and improve the efficacy of mechanical reperfusion with primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI). This study was aimed to evaluate whether the treatment effect of melatonin therapy in patients with STEMI is influenced by the time to administration. We performed a post hoc analysis of the Melatonin Adjunct in the Acute Myocardial Infarction Treated With Angioplasty trial (NCT00640094), which randomized STEMI patients to melatonin (intravenous and intracoronary bolus) or placebo during pPCI. Randomized patients were divided into tertiles according to symptoms onset to balloon time: first tertile (136 ± 23 minutes), second tertile (196 ± 19 minutes), and third tertile (249 ± 41 minutes). Magnetic resonance imaging was performed within 1 week after pPCI. A total of 146 patients presenting with STEMI within 360 minutes of chest pain onset were randomly allocated to intravenous and intracoronary melatonin or placebo during pPCI. In the first tertile, the infarct size was significantly smaller in the melatonin-treated subjects compared with placebo (14.6 ± 14.2 vs 24.9 ± 9.0%; p = 0.003). Contrariwise, treatment with melatonin was associated with a larger infarct size in the group of patients included in the third tertile (20.5 ± 8.7% vs 11.2 ± 5.2%; p = 0.001), resulting in a significant interaction (p = 0.001). In conclusion, the administration of melatonin in patients with STEMI who presented early after symptom onset was associated with a significant reduction in the infarct size after pPCI.

• Publisher: Elsevier Inc,Elsevier Limited
• Subject: Angioplasty / Angioplasty, Balloon, Coronary - methods / Antioxidants - administration & dosage / Cardiovascular / Cardiovascular disease / Coronary vessels / Dose-Response Relationship, Drug / Double-Blind Method / Drug delivery systems / Electrocardiography / Enzyme-Linked Immunosorbent Assay / Female / Follow-Up Studies / Heart attacks / Heart failure / Humans / Injections, Intra-Arterial / Injections, Intravenous / Injury prevention / Intravenous administration / Ischemia / Magnetic resonance imaging / Magnetic Resonance Imaging, Cine - methods / Male / Melatonin / Melatonin - administration & dosage / Middle Aged / Myocardial infarction / Myocardium - metabolism / Myocardium - pathology / Pain / Patients / Percutaneous Coronary Intervention / Randomization / Reperfusion / Severity of Illness Index / ST Elevation Myocardial Infarction - diagnosis / ST Elevation Myocardial Infarction - therapy / Studies / Time Factors / Treatment Outcome / Troponin I - metabolism