Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Tracking the establishment of local endemic populations of an emergent enteric pathogen

by Hien, Tran Tinh , Thuy, Cao Thu , Kim, Dong Wook , Vinh, Ha , Le Phuc, Hoang , Vinh, Phat Voong , Thompson, Corinne , Holt, Kathryn E. , Thi Ngoc Tuyet, Pham , Vu Tra, My Phan , Dong, Nguyen , Thi Nam Lien, Nguyen , Thi Ngoc Dung, Tran , Thanh, Duy Pham , Parry, Christopher M. , Van Minh Hoang, Nguyen , Phu, Bui Duc , Campbell, James I. , Van Minh, Pham , Dougan, Gordon , Parkhill, Julian , Farrar, Jeremy J. , Nga, Tran Thi Thu , Vinh, Nguyen Thanh , Thi Thuy Ai, Nguyen , Thomson, Nicholas R. , Vu Thieu Nga, Tran , Thi Khanh Nhu, Nguyen , Baker, Stephen , Tien, Nguyen Manh

in Anti-Bacterial Agents - therapeutic use / Antimicrobials / Bacteria / Biological Sciences / Child / Child, Preschool / Chromosomes, Bacterial - genetics / Ciprofloxacin - therapeutic use / convergent evolution / Drug resistance / Dysentery / Dysentery, Bacillary - drug therapy / Dysentery, Bacillary - epidemiology / Dysentery, Bacillary - microbiology / Endemic Diseases / enteropathogens / Evolution / Evolution, Molecular / Fluoroquinolones - therapeutic use / Gatifloxacin / gene pool / Genetic mutation / Genetic Variation / genome / Genome, Bacterial - genetics / Genomes / Genomics / Genomics - methods / Geography / Humans / Infant / Infections / Molecular Sequence Data / Mutation Rate / Pathogens / Phylogenetics / Phylogeny / Plasmids / Sequence Analysis, DNA / Shigella / Shigella sonnei / Shigella sonnei - classification / Shigella sonnei - genetics / Shigella sonnei - physiology / Vietnam / Vietnam - epidemiology / Waterborne diseases

2013

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Tracking the establishment of local endemic populations of an emergent enteric pathogen

2013

Confirm

Do you wish to request the book?

Tracking the establishment of local endemic populations of an emergent enteric pathogen

2013

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Tracking the establishment of local endemic populations of an emergent enteric pathogen

Hien, Tran Tinh,

Thuy, Cao Thu,

Kim, Dong Wook,

Vinh, Ha,

Le Phuc, Hoang,

Vinh, Phat Voong,

Thompson, Corinne,

Holt, Kathryn E.,

Thi Ngoc Tuyet, Pham,

Vu Tra, My Phan,

Dong, Nguyen,

Thi Nam Lien, Nguyen,

Thi Ngoc Dung, Tran,

Thanh, Duy Pham,

Parry, Christopher M.,

Van Minh Hoang, Nguyen,

Phu, Bui Duc,

Campbell, James I.,

Van Minh, Pham,

Dougan, Gordon,

Parkhill, Julian,

Farrar, Jeremy J.,

Nga, Tran Thi Thu,

Vinh, Nguyen Thanh,

Thi Thuy Ai, Nguyen,

Thomson, Nicholas R.,

Vu Thieu Nga, Tran,

Thi Khanh Nhu, Nguyen,

Baker, Stephen,

Tien, Nguyen Manh

2013

Overview

Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.

Share this book

Add to My Shelf

Publisher

NATIONAL ACADEMY OF SCIENCES,National Acad Sciences,National Academy of Sciences

Subject

Anti-Bacterial Agents - therapeutic use

/ Antimicrobials

/ Bacteria

/ Biological Sciences

/ Child

/ Child, Preschool

/ Chromosomes, Bacterial - genetics