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Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21
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Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21
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Journal Article
Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21
2010
Overview
Tumor manipulation of host immunity is important for tumor survival and invasion. Many cancers secrete CCL21, a chemoattractant for various leukocytes and lymphoid tissue inducer cells, which drive lymphoid neogenesis. CCL21 expression by melanoma tumors in mice was associated with an immunotolerant microenvironment, which included the induction of lymphoid-like reticular stromal networks, an altered cytokine milieu, and the recruitment of regulatory leukocyte populations. In contrast, CCL21-deficient tumors induced antigen-specific immunity. CCL21-mediated immune tolerance was dependent on host rather than tumor expression of the CCL21 receptor, CCR7, and could protect distant, coimplanted CCL21-deficient tumors and even nonsyngeneic allografts from rejection. We suggest that by altering the tumor microenvironment, CCL21-secreting tumors shift the host immune response from immunogenic to tolerogenic, which facilitates tumor progression.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animal tumors. Experimental tumors
/ Animals
/ Antigen-Presenting Cells - immunology
/ Biological and medical sciences
/ Cancer
/ CD8-Positive T-Lymphocytes - immunology
/ Chemokine CCL21 - metabolism
/ Experimental tumors, general aspects
/ Female
/ Immunity
/ Lymphoid Tissue - immunology
/ Melanoma
/ Melanoma, Experimental - immunology
/ Melanoma, Experimental - pathology
/ Mice
/ Receptors, CCR7 - metabolism
/ T-Lymphocytes, Regulatory - immunology
/ Tumors
