Journal Article

Prevalence, spatial distribution and determinants of complete childhood pneumococcal conjugate vaccination in Ethiopia: spatial and multilevel analyses

Wassie, Mulugeta, Workneh, Belayneh Shetie, Zegeye, Alebachew Ferede, Terefe, Bewuketu, Tamir, Tadesse Tarik

2024

Overview

Introduction Pneumococcal disease is a serious global public health concern. The primary causative agent of severe illnesses such as pneumonia, meningitis, acute otitis media, and bacteremia is the pneumococcus bacterium. The pneumococcal conjugate vaccine is a key strategy to reduce the burden of pneumococcal disease. Understanding the spatial distribution of complete childhood pneumococcal conjugate vaccine utilization and its associated factors is crucial for designing strategies to improve vaccination implementation. Therefore, this study aimed to determine the spatial distribution of complete childhood pneumococcal conjugate vaccination coverage and identify its determinants in Ethiopia. Method A spatial and multilevel analysis was conducted using data from the 2019 Ethiopian Mini Demographic and Health Survey. The analysis included a total of 2,055 weighted children. The association between the outcome variable and the explanatory variables was determined by calculating adjusted odds ratios at a 95% confidence interval. Explanatory variables were considered significantly associated with the outcome if the p-value was less than 0.05. Result The prevalence of complete childhood pneumococcal conjugate vaccination in Ethiopia was 53.94% (95% CI: 51.77, 56.08). Higher complete childhood pneumococcal vaccination coverage was observed in the Addis Ababa, Tigray, Amhara, Benishangul-Gumuz, and Oromia regions, while lower coverage was seen in the Afar, Somali, and SNNPR regions of Ethiopia. Factors significantly associated with complete childhood pneumococcal conjugate vaccination included maternal age, antenatal care visits, place of delivery, region, community women’s literacy level, community poverty level, and community antenatal care utilization. Conclusion The distribution of complete childhood pneumococcal conjugate vaccination exhibited spatial variability across Ethiopia. Approximately half of children aged twelve to thirty-five months received the full dose of the childhood pneumococcal conjugate vaccine in the country. Several factors were identified as statistically significant determinants of complete childhood pneumococcal conjugate vaccination, including maternal age, antenatal care visits, place of delivery, region, community women’s literacy level, community poverty level, and community ANC utilization. Therefore, policies and strategies aimed at combating pneumococcal disease should consider these determinants and address areas with low vaccination coverage.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adolescent / Adult / Age / Analysis / Bacteremia / Bacterial pneumonia / Biostatistics / Care and treatment / Child, Preschool / Childhood / Children / Complications and side effects / Confidence intervals / Conjugates / Datasets / Demographic aspects / Demographic variables / Distribution / Dosage and administration / Environmental Health / Epidemiology / Ethiopia / Ethiopia - epidemiology / Female / Health surveys / Households / Humans / Illiteracy / Immunization / Infant / Literacy / Male / Medicine / Medicine & Public Health / Meningitis / Multilevel Analysis / Otitis media / Parent educational background / Pneumococcal infections / Pneumococcal Infections - epidemiology / Pneumococcal Infections - prevention & control / Pneumococcal vaccine / Pneumococcal Vaccines - administration & dosage / Pneumococcus / Pneumonia / Poverty / Prenatal care / Prevalence / Prevalence studies (Epidemiology) / Public Health / Regression analysis / Spatial Analysis / Spatial distribution / Statistical analysis / Utilization / Vaccination / Vaccination Coverage - statistics & numerical data / Vaccine / Vaccines / Vaccines, Conjugate - administration & dosage / Variables / Young Adult