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Echinacea purpurea for Prevention of Experimental Rhinovirus Colds
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Echinacea purpurea for Prevention of Experimental Rhinovirus Colds
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Journal Article
Echinacea purpurea for Prevention of Experimental Rhinovirus Colds
2004
Overview
A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the ability of Echinacea purpurea to prevent infection with rhinovirus type 39 (RV-39). Forty-eight previously healthy adults received echinacea or placebo, 2.5 mL 3 times per day, for 7 days before and 7 days after intranasal inoculation with RV-39. Symptoms were assessed to evaluate clinical illness. Viral culture and serologic studies were performed to evaluate the presence of rhinovirus infection. A total of 92% of echinacea recipients and 95% of placebo recipients were infected. Colds developed in 58% of echinacea recipients and 82% of placebo recipients (P = .114, by Fisher's exact test). Administration of echinacea before and after exposure to rhinovirus did not decrease the rate of infection; however, because of the small sample size, statistical hypothesis testing had relatively poor power to detect statistically significant differences in the frequency and severity of illness.
Publisher
The University of Chicago Press,University of Chicago Press
Subject
/ Adult
/ Aged
/ Biological and medical sciences
/ Common Cold - prevention & control
/ Diseases
/ Female
/ Herbs
/ Humans
/ Major
/ Male
/ Otorhinolaryngology. Stomatology
/ Placebos
/ Plant Extracts - adverse effects
/ Plant Extracts - therapeutic use
/ Symptoms
/ Viral diseases of the respiratory system and ent viral diseases
/ Viruses
