Journal Article

Radiologic complete response (rCR) in contrast-enhanced magnetic resonance imaging (CE-MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence-free survival but not pathologic complete response (pCR)

Reitsamer, Roland, Weismann, Christian, Westphal, Theresa, Peer, Andreas, Gampenrieder, Simon Peter, Riedmann, Marina, Mlineritsch, Brigitte, Egger, Heike, Stering, Katharina, Rinnerthaler, Gabriel, Hergan, Klaus, Meissnitzer, Matthias, Klaassen Federspiel, Frederike, Hauser-Kronberger, Cornelia, Greil, Richard, Webhofer, Johanna, Meissnitzer, Thomas

2019

Overview

Background Patients with early breast cancer (EBC) achieving pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) have a favorable prognosis. Breast surgery might be avoided in patients in whom the presence of residual tumor can be ruled out with high confidence. Here, we investigated the diagnostic accuracy of contrast-enhanced MRI (CE-MRI) in predicting pCR and long-term outcome after NACT. Methods Patients with EBC, including patients with locally advanced disease, who had undergone CE-MRI after NACT, were retrospectively analyzed ( n  = 246). Three radiologists, blinded to clinicopathologic data, reevaluated all MRI scans regarding to the absence (radiologic complete remission; rCR) or presence (no-rCR) of residual contrast enhancement. Clinical and pathologic responses were compared categorically using Cohen’s kappa statistic. The Kaplan-Meier method was used to estimate recurrence-free survival (RFS) and overall survival (OS). Results Overall rCR and pCR (no invasive tumor in the breast and axilla (ypT0/is N0)) rates were 45% (111/246) and 29% (71/246), respectively. Only 48% (53/111; 95% CI 38–57%) of rCR corresponded to a pCR (= positive predictive value - PPV). Conversely, in 87% (117/135; 95% CI 79–92%) of patients, residual tumor observed on MRI was pathologically confirmed (= negative predictive value - NPV). Sensitivity to detect a pCR was 75% (53/71; 95% CI 63–84%), while specificity to detect residual tumor and accuracy were 67% (117/175; 95% CI 59–74%) and 69% (170/246; 95% CI 63–75%), respectively. The PPV was significantly lower in hormone-receptor (HR)-positive compared to HR-negative tumors (17/52 = 33% vs. 36/59 = 61%; P  = 0.004). The concordance between rCR and pCR was low (Cohen’s kappa − 0.1), however in multivariate analysis both assessments were significantly associated with RFS (rCR P  = 0.037; pCR P  = 0.033) and OS (rCR P = 0.033; pCR P  = 0.043). Conclusion Preoperative CE-MRI did not accurately predict pCR after NACT for EBC, especially not in HR-positive tumors. However, rCR was strongly associated with favorable RFS and OS.

• Publisher: BioMed Central,Springer Nature B.V,BMC
• Subject: Accuracy / Adult / Aged / Aged, 80 and over / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Biomedical and Life Sciences / Biomedicine / Biopsy / Breast - diagnostic imaging / Breast - pathology / Breast - surgery / Breast cancer / Breast Neoplasms - diagnostic imaging / Breast Neoplasms - mortality / Breast Neoplasms - pathology / Breast Neoplasms - therapy / Cancer Research / Cancer therapies / Chemotherapy / Contrast Media - administration & dosage / Disease-Free Survival / Female / Follow-Up Studies / Humans / Invasiveness / Kaplan-Meier Estimate / Magnetic resonance imaging / Magnetic Resonance Imaging - methods / Mammography / Mastectomy / Medical imaging / Medical prognosis / Middle Aged / MRI / Multivariate analysis / Neoadjuvant chemotherapy / Neoadjuvant Therapy - methods / Neoplasm Recurrence, Local - diagnosis / Neoplasm, Residual / NMR / Nuclear magnetic resonance / Oncology / Prediction of complete pathologic response / Predictive Value of Tests / Preoperative Period / Prognosis / Remission / Research Article / Retrospective Studies / Surgery / Surgical Oncology / Survival / Tumors / Young Adult