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Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2
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Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2
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Journal Article
Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2
2021
Overview
Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection, it is imperative that we provide interventions to keep them at bay, especially in immunocompromised patients. While numerous experimental vaccines are under consideration, current intervention consists solely of antiviral chemotherapeutic agents. This review explores all of the clinically approved drugs used to prevent the worst sequelae of recurrent outbreaks by these viruses.
Publisher
MDPI AG,MDPI
Subject
/ Antiviral Agents - adverse effects
/ Antiviral Agents - pharmacokinetics
/ Antiviral Agents - pharmacology
/ Antiviral Agents - therapeutic use
/ DNA-Directed DNA Polymerase - metabolism
/ Enzymes
/ Herpes Simplex - drug therapy
/ Herpesvirus 1, Human - drug effects
/ Herpesvirus 2, Human - drug effects
/ Humans
/ Mutation
/ Nucleic Acid Synthesis Inhibitors - adverse effects
/ Nucleic Acid Synthesis Inhibitors - pharmacokinetics
/ Nucleic Acid Synthesis Inhibitors - pharmacology
/ Nucleic Acid Synthesis Inhibitors - therapeutic use
/ Review
/ Virus Attachment - drug effects
/ Virus Internalization - drug effects
/ Viruses
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