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The Neurovascular Unit in Dementia: An Opinion on Current Research and Future Directions
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The Neurovascular Unit in Dementia: An Opinion on Current Research and Future Directions
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Journal Article
The Neurovascular Unit in Dementia: An Opinion on Current Research and Future Directions
2021
Overview
[...]the lack of efficacy for amyloid-based targets may suggest amyloid is a by-product rather than causative agent of the disease process. [...]the potential efficacy in a sub-group of early AD (Tolar et al., 2020) suggests that amyloid is a late occurrence in the disease process, at which stage irrevocable damage and cognitive decline has ensued. [...]amyloid deposition damages the cerebrovasculature, both structurally and functionally, therefore worsening hypoperfusion in a cyclical fashion (Nelson et al., 2016). [...]deficiencies occurring in one or more components of the NVU threaten this tightly coordinated system.
Publisher
Frontiers Research Foundation,Frontiers Media S.A
Subject
/ Dementia
