Journal Article

Donor-site morbidity after osteochondral autologous transplantation for osteochondritis dissecans of the capitellum: a systematic review and meta-analysis

Bexkens, Rens, Ogink, Paul T., Eygendaal, Denise, van den Bekerom, Michel P. J., Doornberg, Job N., Kerkhoffs, Gino M. M. J., Oh, Luke S.

2017

Overview

Purpose To determine the rate of donor-site morbidity after osteochondral autologous transplantation (OATS) for capitellar osteochondritis dissecans. Methods A literature search was performed in PubMed/MEDLINE, Embase, and Cochrane Library to identify studies up to November 6, 2016. Criteria for inclusion were OATS for capitellar osteochondritis dissecans, reported outcomes related to donor sites, ≥10 patients, ≥1 year follow-up, and written in English. Donor-site morbidity was defined as persistent symptoms (≥1 year) or cases that required subsequent intervention. Patient and harvest characteristics were described, as well as the rate of donor-site morbidity. A random effects model was used to calculate and compare weighted group proportions. Results Eleven studies including 190 patients were included. In eight studies, grafts were harvested from the femoral condyle, in three studies, from either the 5th or 6th costal-osteochondral junction. The average number of grafts was 2 (1–5); graft diameter ranged from 2.6 to 11 mm. In the knee-to-elbow group, donor-site morbidity was reported in 10 of 128 patients (7.8%), knee pain during activity (7.0%) and locking sensations (0.8%). In the rib-to-elbow group, one of 62 cases (1.6%) was complicated, a pneumothorax. The proportion in the knee-to-elbow group was 0.04 (95% CI 0.0–0.15), and the proportion in the rib-to-elbow group was 0.01 (95% CI 0.00–0.06). There were no significant differences between both harvest techniques (n.s.). Conclusions Donor-site morbidity after OATS for capitellar osteochondritis dissecans was reported in a considerable group of patients. Level of evidence Level IV, systematic review of level IV studies.

• Publisher: Springer Berlin Heidelberg,John Wiley & Sons, Inc
• Subject: Arthralgia - etiology / Autografts / Bone Transplantation - adverse effects / Bone Transplantation - methods / Elbow / Elbow Joint - surgery / Femur / Femur - transplantation / Grafting / Humans / Intervention / Knee / Knee Joint - pathology / Literature reviews / Medicine / Medicine & Public Health / Meta-analysis / Morbidity / Oats / Orthopedics / Osteochondritis / Osteochondritis dissecans / Osteochondritis Dissecans - etiology / Osteochondritis Dissecans - surgery / Pain / Pneumothorax / Postoperative Complications - pathology / Rib / Ribs - transplantation / Skin & tissue grafts / Systematic review / Transplant Donor Site - pathology / Transplantation / Transplantation, Autologous