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Urban wastewater analysis as an effective tool for monitoring illegal drugs, including new psychoactive substances, in the Eastern European region
by
Dereziński, Paweł
, Matysiak, Jan
, Przybyłowski, Piotr
, Kokot, Zenon J.
, Klupczynska, Agnieszka
, Sulej-Suchomska, Anna Maria
in
704/172/169/895
/ 704/844
/ Cannabis
/ Chromatography, High Pressure Liquid
/ Cocaine
/ Consumption patterns
/ Drug abuse
/ Epidemiology
/ Europe, Eastern
/ Freeze-thawing
/ Heroin
/ High-performance liquid chromatography
/ Humanities and Social Sciences
/ Humans
/ Illicit Drugs - analysis
/ Ketamine
/ Liquid chromatography
/ Mass spectrometry
/ Mass spectroscopy
/ Metabolites
/ Morphine Derivatives - analysis
/ multidisciplinary
/ Psychotropic Drugs - analysis
/ Science
/ Science (multidisciplinary)
/ Sewage
/ Solid Phase Extraction
/ Tandem Mass Spectrometry
/ Tetrahydrocannabinol
/ Urban Health
/ Waste Water - analysis
/ Wastewater
/ Wastewater analysis
2020
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Urban wastewater analysis as an effective tool for monitoring illegal drugs, including new psychoactive substances, in the Eastern European region
by
Dereziński, Paweł
, Matysiak, Jan
, Przybyłowski, Piotr
, Kokot, Zenon J.
, Klupczynska, Agnieszka
, Sulej-Suchomska, Anna Maria
in
704/172/169/895
/ 704/844
/ Cannabis
/ Chromatography, High Pressure Liquid
/ Cocaine
/ Consumption patterns
/ Drug abuse
/ Epidemiology
/ Europe, Eastern
/ Freeze-thawing
/ Heroin
/ High-performance liquid chromatography
/ Humanities and Social Sciences
/ Humans
/ Illicit Drugs - analysis
/ Ketamine
/ Liquid chromatography
/ Mass spectrometry
/ Mass spectroscopy
/ Metabolites
/ Morphine Derivatives - analysis
/ multidisciplinary
/ Psychotropic Drugs - analysis
/ Science
/ Science (multidisciplinary)
/ Sewage
/ Solid Phase Extraction
/ Tandem Mass Spectrometry
/ Tetrahydrocannabinol
/ Urban Health
/ Waste Water - analysis
/ Wastewater
/ Wastewater analysis
2020
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Urban wastewater analysis as an effective tool for monitoring illegal drugs, including new psychoactive substances, in the Eastern European region
by
Dereziński, Paweł
, Matysiak, Jan
, Przybyłowski, Piotr
, Kokot, Zenon J.
, Klupczynska, Agnieszka
, Sulej-Suchomska, Anna Maria
in
704/172/169/895
/ 704/844
/ Cannabis
/ Chromatography, High Pressure Liquid
/ Cocaine
/ Consumption patterns
/ Drug abuse
/ Epidemiology
/ Europe, Eastern
/ Freeze-thawing
/ Heroin
/ High-performance liquid chromatography
/ Humanities and Social Sciences
/ Humans
/ Illicit Drugs - analysis
/ Ketamine
/ Liquid chromatography
/ Mass spectrometry
/ Mass spectroscopy
/ Metabolites
/ Morphine Derivatives - analysis
/ multidisciplinary
/ Psychotropic Drugs - analysis
/ Science
/ Science (multidisciplinary)
/ Sewage
/ Solid Phase Extraction
/ Tandem Mass Spectrometry
/ Tetrahydrocannabinol
/ Urban Health
/ Waste Water - analysis
/ Wastewater
/ Wastewater analysis
2020
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Urban wastewater analysis as an effective tool for monitoring illegal drugs, including new psychoactive substances, in the Eastern European region
Journal Article
Urban wastewater analysis as an effective tool for monitoring illegal drugs, including new psychoactive substances, in the Eastern European region
2020
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Overview
The use of illicit drugs causes unquestionable societal and economic damage. To implement actions aimed at combating drug abuse, it is necessary to assess illicit drug consumption patterns. The purpose of this paper was to develop, optimize, validate and apply a procedure for determining new psychoactive substances (NPSs) and classic drugs of abuse and their main metabolites in wastewater samples by using solid phase extraction (SPE) and high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). Moreover, detailed validation of the procedure was conducted. The developed SPE–HPLC-MS/MS procedure (within the sewage-based epidemiology strategy) allowed for the simultaneous, selective, very sensitive, accurate (recoveries ≥ 80.1%) and precise (CV ≤ 8.1%) determination of new and classic psychoactive substances in wastewater samples. This study is characterized by new scientific elements, especially in terms of the freeze-thaw and post-preparative stability of the selected psychoactive substances. This is the first time that NPSs (mephedrone and ketamine), the main metabolites of heroin (6-acetylmorphine, 6-AM) and marijuana (11-nor-9-carboxy-Δ9-tetrahydrocannabinol, THC-COOH) have been detected and monitored in Poland. This study is also the first to corroborate the data available from the EMCDDA and EUROPOL report and indicates that the retail market for cocaine is expanding in Eastern Europe.
Publisher
Nature Publishing Group UK,Nature Publishing Group
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