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Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine
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Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine
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Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine
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Journal Article
Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine
2006
Overview
Conventional hepatitis B vaccines do not elicit adequate antibody production in 5–10% vaccinees. This trial tests the ability of a third-generation vaccine, containing PreS1 and PreS2 antigens in addition to the S antigen, to elicit seroprotective titres in documented non- and low-responders, compared with those to a conventional vaccine. In the primary population of non-responders (<10
IU/l anti-HBs antibodies after ≥4 previous injections of conventional vaccine) an enhanced antibody response was seen to additional injections of the third-generation vaccine compared with a conventional vaccine (absolute difference 14.9%;
P
=
0.006). Enhanced antibody responses were also found in a population that included low responders.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Age
/ Aged
/ Antigens
/ Biological and medical sciences
/ Disease
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Hepatitis B - prevention & control
/ Hepatitis B Antibodies - blood
/ Hepatitis B Surface Antigens - administration & dosage
/ Hepatitis B Surface Antigens - immunology
/ Hepatitis B Vaccines - administration & dosage
/ Hepatitis B Vaccines - adverse effects
/ Hepatitis B Vaccines - immunology
/ Humans
/ Male
/ Mammalian cell derived PreS 1/PreS 2/S third-generation vaccine
/ Protein Precursors - administration & dosage
/ Protein Precursors - immunology
/ Proteins
/ Vaccines
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
/ Yeast
