Journal Article

Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study

West, Sheila G., Jones, Peter J. H., Wilson, Angela, Zahradka, Peter, Letourneau, Karen, Kris-Etherton, Penny M., Perera, Danielle, Davis, Kristin M., Bowen, Kate J., Wagner, Paul R., Petersen, Kristina S., Taylor, Carla G.

2022

Overview

Partial replacement of saturated fatty acids (SFA) with unsaturated fatty acids is recommended to reduce cardiovascular disease (CVD) risk. Monounsaturated fatty acids (MUFA), including oleic acid, are associated with lower CVD risk. Measurement of flow-mediated dilation of the brachial artery (FMD) is the gold standard for measuring endothelial function and predicts CVD risk. This study examined the effect of partially replacing SFA with MUFA from conventional canola oil and high-oleic acid canola oil on FMD. Participants (n = 31) with an elevated waist circumference plus ≥1 additional metabolic syndrome criterion completed FMD measures as part of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a multi-center, double-blind, three-period crossover, controlled feeding randomized trial. Diet periods were 6 weeks, separated by ≥4-week washouts. Experimental diets were provided during all feeding periods. Diets only differed by the fatty acid profile of the oils: canola oil (CO; 17.5% energy from MUFA, 9.2% polyunsaturated fatty acids (PUFA), 6.6% SFA), high-oleic acid canola oil (HOCO; 19.1% MUFA, 7.0% PUFA, 6.4% SFA), and a control oil blend (CON; 11% MUFA, 10% PUFA, 12% SFA). Multilevel models were used to examine the effect of the diets on FMD. No significant between-diet differences were observed for average brachial artery diameter (CO: 6.70 ± 0.15 mm, HOCO: 6.57 ± 0.15 mm, CON: 6.73 ± 0.14 mm; p = 0.72), peak brachial artery diameter (CO: 7.11 ± 0.15 mm, HOCO: 7.02 ± 0.15 mm, CON: 6.41 ± 0.48 mm; p = 0.80), or FMD (CO: 6.32 ± 0.51%, HOCO: 6.96 ± 0.49%, CON: 6.41 ± 0.48%; p = 0.81). Partial replacement of SFA with MUFA from CO and HOCO had no effect on FMD in participants with or at risk of metabolic syndrome.

• Publisher: MDPI AG,MDPI
• Subject: Abdomen / Atherosclerosis / Blood pressure / Calories / Canola / Canola oil / Cardiovascular disease / Cardiovascular diseases / Cardiovascular Diseases - prevention & control / Cross-Over Studies / Diabetes / Diet / energy / Enriched foods / fatty acid composition / Fatty acids / Fatty Acids - pharmacology / Fatty Acids, Monounsaturated / Fatty Acids, Unsaturated / Health aspects / Humans / Linoleic acids / Lipids / metabolic syndrome / Metabolic Syndrome - prevention & control / Metabolic syndrome X / Nutritional aspects / Oils & fats / Oleic Acid / Polyunsaturated fatty acids / Prevention / Rapeseed Oil - pharmacology / risk / Trans fats / Ultrasonic imaging / Vascular endothelium / waist circumference / Womens health