Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo
by
Eisel, Jessica
, Kaulfuss, Stefan
, Neuhaus, Roland
, Hillig, Roman C.
, Bauser, Markus
, Krausert, Sonja
, Sahm, Felix
, Schrimpf, Daniel
, Pusch, Stefan
, Wick, Wolfgang
, Balss, Jörg
, Zimmermann, Katja
, Hess-Stumpp, Holger
, Fischer, Viktoria
, Ott, Martina
, Jugold, Manfred
, Platten, Michael
, Eichwald, Viktoria
, Unterberg, Andreas
, Herold-Mende, Christel
, Rehwinkel, Hartmut
, von Deimling, Andreas
, Guenther, Judith
, Toschi, Luisella
, Haegebart, Andrea
, Capper, David
, Beck, Ann-Christin
, Panknin, Olaf
in
Aniline Compounds - chemistry
/ Aniline Compounds - pharmacokinetics
/ Aniline Compounds - pharmacology
/ Aniline Compounds - toxicity
/ Animals
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - pharmacokinetics
/ Antineoplastic Agents - pharmacology
/ Antineoplastic Agents - toxicity
/ Astrocytoma - drug therapy
/ Astrocytoma - enzymology
/ Astrocytoma - genetics
/ Benzimidazoles - chemistry
/ Benzimidazoles - pharmacokinetics
/ Benzimidazoles - pharmacology
/ Benzimidazoles - toxicity
/ Brain cancer
/ Brain Neoplasms - drug therapy
/ Brain Neoplasms - enzymology
/ Brain Neoplasms - genetics
/ Brain research
/ Cancer research
/ Cell Line, Tumor
/ Cell Survival - drug effects
/ Cell Survival - physiology
/ Codons
/ Colonic Neoplasms - drug therapy
/ Colonic Neoplasms - enzymology
/ Colonic Neoplasms - genetics
/ Cooperation
/ Dehydrogenases
/ Enzyme Inhibitors - chemistry
/ Enzyme Inhibitors - pharmacokinetics
/ Enzyme Inhibitors - pharmacology
/ Enzyme Inhibitors - toxicity
/ Enzymes
/ Escherichia coli
/ Female
/ Genetic aspects
/ Gliomas
/ Glutarates - metabolism
/ HEK293 Cells
/ Humans
/ Isocitrate Dehydrogenase - antagonists & inhibitors
/ Isocitrate Dehydrogenase - genetics
/ Isocitrate Dehydrogenase - metabolism
/ Leukemia
/ Medical research
/ Medicine
/ Medicine & Public Health
/ Mice, Inbred BALB C
/ Mice, Nude
/ Mutation
/ Neuropathology
/ Neurosciences
/ Neurosurgery
/ Original Paper
/ Pathology
/ Proteins
/ R&D
/ Recombinant Proteins - genetics
/ Recombinant Proteins - metabolism
/ Research & development
/ Research centers
/ Sarcoma - drug therapy
/ Sarcoma - enzymology
/ Sarcoma - genetics
/ Sf9 Cells
/ Survival analysis
/ Tumors
/ Xenograft Model Antitumor Assays
2017