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Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
by
Bumrungpert, Akkarach
, Lilitchan, Supathra
, Komindr, Surat
, Tuntipopipat, Siriporn
, Tirawanchai, Nednapis
in
Acids
/ anti-inflammation
/ anti-oxidant
/ Biomarkers
/ Blindness
/ Cardiovascular diseases
/ Cholesterol
/ Clinical trials
/ Ferulic acid
/ Health risks
/ High density lipoprotein
/ Hyperlipidemia
/ Inflammation
/ lipid profiles
/ Lipids
/ Low density lipoprotein
/ Oxidative stress
/ phenolic compound
/ Phenolic compounds
/ Phenols
/ Randomization
/ Risk analysis
/ Risk factors
/ Significance
/ Statistical analysis
/ Supplementation
/ Tumor necrosis factor-α
2018
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Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
by
Bumrungpert, Akkarach
, Lilitchan, Supathra
, Komindr, Surat
, Tuntipopipat, Siriporn
, Tirawanchai, Nednapis
in
Acids
/ anti-inflammation
/ anti-oxidant
/ Biomarkers
/ Blindness
/ Cardiovascular diseases
/ Cholesterol
/ Clinical trials
/ Ferulic acid
/ Health risks
/ High density lipoprotein
/ Hyperlipidemia
/ Inflammation
/ lipid profiles
/ Lipids
/ Low density lipoprotein
/ Oxidative stress
/ phenolic compound
/ Phenolic compounds
/ Phenols
/ Randomization
/ Risk analysis
/ Risk factors
/ Significance
/ Statistical analysis
/ Supplementation
/ Tumor necrosis factor-α
2018
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Do you wish to request the book?
Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
by
Bumrungpert, Akkarach
, Lilitchan, Supathra
, Komindr, Surat
, Tuntipopipat, Siriporn
, Tirawanchai, Nednapis
in
Acids
/ anti-inflammation
/ anti-oxidant
/ Biomarkers
/ Blindness
/ Cardiovascular diseases
/ Cholesterol
/ Clinical trials
/ Ferulic acid
/ Health risks
/ High density lipoprotein
/ Hyperlipidemia
/ Inflammation
/ lipid profiles
/ Lipids
/ Low density lipoprotein
/ Oxidative stress
/ phenolic compound
/ Phenolic compounds
/ Phenols
/ Randomization
/ Risk analysis
/ Risk factors
/ Significance
/ Statistical analysis
/ Supplementation
/ Tumor necrosis factor-α
2018
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Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Journal Article
Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
2018
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Overview
Ferulic acid is the most abundant phenolic compound found in vegetables and cereal grains. In vitro and animal studies have shown ferulic acid has anti-hyperlipidemic, anti-oxidative, and anti-inflammatory effects. The objective of this study is to investigate the effects of ferulic acid supplementation on lipid profiles, oxidative stress, and inflammatory status in hyperlipidemia. The study design is a randomized, double-blind, placebo-controlled trial. Subjects with hyperlipidemia were randomly divided into two groups. The treatment group (
= 24) was given ferulic acid (1000 mg daily) and the control group (
= 24) was provided with a placebo for six weeks. Lipid profiles, biomarkers of oxidative stress and inflammation were assessed before and after the intervention. Ferulic acid supplementation demonstrated a statistically significant decrease in total cholesterol (8.1%;
= 0.001), LDL-C (9.3%;
< 0.001), triglyceride (12.1%;
= 0.049), and increased HDL-C (4.3%;
= 0.045) compared with the placebo. Ferulic acid also significantly decreased the oxidative stress biomarker, MDA (24.5%;
< 0.001). Moreover, oxidized LDL-C was significantly decreased in the ferulic acid group (7.1%;
= 0.002) compared with the placebo group. In addition, ferulic acid supplementation demonstrated a statistically significant reduction in the inflammatory markers hs-CRP (32.66%;
< 0.001) and TNF-α (13.06%;
< 0.001). These data indicate ferulic acid supplementation can improve lipid profiles and oxidative stress, oxidized LDL-C, and inflammation in hyperlipidemic subjects. Therefore, ferulic acid has the potential to reduce cardiovascular disease risk factors.
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