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Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder
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Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder
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Journal Article
Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder
2002
Overview
A novel form of inflammatory bowel disease has been reported in a cohort of children with developmental disorder, manifesting predominantly as regressive autism (affected children). The intestinal pathology includes ileo-colonic lymphoid nodular hyperplasia (LNH) and a subtle enterocolitis. Clinical and pathological aspects of this disorder have previously been reported. In ileal lymphoid tissues of affected children, the presence of reactive follicular hyperplasia may reflect antigenic presence at this site. We have examined a possible association between measles virus (MV) and a chronic enterocolitis in these children. We sought to detect and localise MV in intestinal tissues from affected children.
Publisher
Nature Publishing Group
Subject
/ Biopsy
/ Child
/ Children
/ Dendritic Cells, Follicular - immunology
/ Dendritic Cells, Follicular - virology
/ Developmental Disabilities - etiology
/ Developmental Disabilities - virology
/ Enterocolitis - complications
/ Female
/ Genomes
/ Humans
/ Identification and classification
/ Inflammatory Bowel Diseases - complications
/ Inflammatory Bowel Diseases - immunology
/ Intestinal Mucosa - immunology
/ Intestinal Mucosa - virology
/ Male
/ Measles
/ Measles virus - isolation & purification
/ Measles virus - pathogenicity
/ Pseudolymphoma - complications
/ Reverse Transcriptase Polymerase Chain Reaction
/ RNA, Viral - isolation & purification
/ Subacute Sclerosing Panencephalitis - virology
/ Viruses
