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Protein phosphatase 2A interacts with Verthandi/Rad21 to regulate mitosis and organ development in Drosophila
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Protein phosphatase 2A interacts with Verthandi/Rad21 to regulate mitosis and organ development in Drosophila
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Protein phosphatase 2A interacts with Verthandi/Rad21 to regulate mitosis and organ development in Drosophila
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Journal Article
Protein phosphatase 2A interacts with Verthandi/Rad21 to regulate mitosis and organ development in Drosophila
2019
Overview
Rad21/Scc1 is a subunit of the cohesin complex implicated in gene regulation as well as sister chromatid cohesion. The level of Rad21/Scc1 must be controlled for proper mitosis and gene expression during development. Here, we identify the PP2A catalytic subunit encoded by
microtubule star
(
mts
) as a regulator of
Drosophila
Rad21/Verthandi (Vtd). Mutations in
mts
and
vtd
cause synergistic mitotic defects, including abnormal spindles and loss of nuclei during nuclear division in early embryo. Depletion of Mts and Vtd in developing wing synergistically reduces the Cut protein level, causing severe defects in wing growth. Mts and PP2A subunit Twins (Tws) interact with Vtd protein. Loss of Mts or Tws reduces Vtd protein level. Reduced proteasome function suppresses mitotic defects caused by mutations in
mts
and
vtd
. Taken together, this work provides evidence that PP2A is required for mitosis and wing growth by regulating the Vtd level through the proteasomal pathway.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/109
/ 13/51
/ 13/89
/ 14/1
/ 14/19
/ 14/34
/ 14/35
/ 45/29
/ 631/136
/ 64/24
/ 82/80
/ 82/83
/ Animals
/ Cell Cycle Proteins - metabolism
/ Cohesin
/ Defects
/ Drosophila Proteins - metabolism
/ Humanities and Social Sciences
/ Insects
/ Mitosis
/ Mutation
/ Proteasome Endopeptidase Complex - metabolism
/ Protein Phosphatase 2 - metabolism
/ Protein Subunits - metabolism
/ Proteins
/ Science
/ Spindle Apparatus - metabolism
/ Spindles
