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Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated from Polysiphonia morrowii in IgE/BSA-Stimulated Mast Cells and a Passive Cutaneous Anaphylaxis Mouse Model
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Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated from Polysiphonia morrowii in IgE/BSA-Stimulated Mast Cells and a Passive Cutaneous Anaphylaxis Mouse Model
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Journal Article
Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated from Polysiphonia morrowii in IgE/BSA-Stimulated Mast Cells and a Passive Cutaneous Anaphylaxis Mouse Model
2022
Overview
In this study, we investigated the anti-allergic effects of 3,4-dihydroxybenzaldehyde (DHB) isolated from the marine red alga, Polysiphonia morrowii, in mouse bone-marrow-derived cultured mast cells (BMCMCs) and passive cutaneous anaphylaxis (PCA) in anti-dinitrophenyl (DNP) immunoglobulin E (IgE)-sensitized mice. DHB inhibited IgE/bovine serum albumin (BSA)-induced BMCMCs degranulation by reducing the release of β-hexosaminidase without inducing cytotoxicity. Further, DHB dose-dependently decreased the IgE binding and high-affinity IgE receptor (FcεRI) expression and FcεRI-IgE binding on the surface of BMCMCs. Moreover, DHB suppressed the secretion and/or the expression of the allergic cytokines, interleukin (IL)-4, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF)-α, and the chemokine, thymus activation-regulated chemokine (TARC), by regulating the phosphorylation of IκBα and the translocation of cytoplasmic NF-κB into the nucleus. Furthermore, DHB attenuated the passive cutaneous anaphylactic (PCA) reaction reducing the exuded Evans blue amount in the mouse ear stimulated by IgE/BSA. These results suggest that DHB is a potential therapeutic candidate for the prevention and treatment of type I allergic disorders.
Publisher
MDPI AG,MDPI
Subject
/ Animals
/ Anti-Allergic Agents - administration & dosage
/ Anti-Allergic Agents - isolation & purification
/ Anti-Allergic Agents - pharmacology
/ Antigens
/ Benzaldehydes - administration & dosage
/ Benzaldehydes - isolation & purification
/ Benzaldehydes - pharmacology
/ Binding
/ bone marrow-derived cultured mast cells
/ Catechols - administration & dosage
/ Catechols - isolation & purification
/ Dose-Response Relationship, Drug
/ ears
/ Immunoglobulin E - immunology
/ Male
/ Mice
/ Necrosis
/ Passive cutaneous anaphylaxis
/ Passive Cutaneous Anaphylaxis - drug effects
/ Passive Cutaneous Anaphylaxis - immunology
/ Serum
/ Serum Albumin, Bovine - immunology
/ Toxicity
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