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LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration
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LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration
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Journal Article
LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration
2015
Overview
Emerging studies document the roles of long non-coding RNAs （LncRNAs） in regulating gene expression at chromatin level but relatively less is known how they regulate DNA methylation. Here we identify an lncRNA, Dum （developmental pluripotency-associated 2 （Dppa2） Upstream binding Muscle IncRNA） in skeletal myoblast cells. The expression of Dum is dynamically regulated during myogenesis in vitro and in vivo. It is also transcriptionally induced by MyoD binding upon myoblast differentiation. Functional analyses show that it promotes myoblast differentiation and damage-induced muscle regeneration. Mechanistically, Dum was found to silence its neighboring gene, Dppa2, in cis through recruiting Dnmtl, Dnmt3a and Dnmt3b. Furthermore, intrachromosomal looping between Dum locus and Dppa2 promoter is necessary for Dum/Dppa2 interaction. Collectively, we have identified a novel IncRNA that interacts with Dnmts to regulate myogenesis.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ Cell Differentiation - genetics
/ DNA (Cytosine-5-)-Methyltransferase 1
/ DNA (Cytosine-5-)-Methyltransferases - genetics
/ DNA甲基化
/ Mice
/ Muscle Development - genetics
/ Muscle Development - physiology
/ Muscle, Skeletal - growth & development
/ Nuclear Proteins - biosynthesis
/ Original
/ Promoter Regions, Genetic - genetics
/ RNA, Long Noncoding - genetics
/ 再生
/ 相互作用
/ 细胞分化
/ 肌肉发生
/ 调控基因表达
/ 转移酶
/ 非编码RNA
