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Human Herpesvirus-6 Infection in Children -- A Prospective Study of Complications and Reactivation

by Caserta, Mary T , Long, Christine E , Epstein, Leon G , McIntyre, Kim M , Knott, Anne , Dewhurst, Stephen , Insel, Richard A , Hall, Caroline Breese , Schnabel, Kenneth C , Costanzo, Maria A

in Acute Disease / Age / Antibodies, Viral - biosynthesis / Base Sequence / Bone marrow / Cell culture / Child, Preschool / Children / Children & youth / DNA Primers / DNA, Viral - isolation & purification / Follow-Up Studies / Genomes / Health risk assessment / Herpesviridae Infections - complications / Herpesviridae Infections - diagnosis / Herpesviridae Infections - microbiology / Herpesvirus 6, Human - genetics / Herpesvirus 6, Human - growth & development / Herpesvirus 6, Human - isolation & purification / Humans / Illnesses / Infant, Newborn / Infants / Infections / Laboratories / Molecular Sequence Data / Newborn babies / Pediatrics / Polymerase Chain Reaction / Prospective Studies / Seizures / Seroconversion / Studies / Transplants & implants / Treatment Outcome / Viremia / Viremia - complications / Viremia - diagnosis / Viremia - microbiology / Virus Activation

1994

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Human Herpesvirus-6 Infection in Children -- A Prospective Study of Complications and Reactivation

by Caserta, Mary T , Long, Christine E , Epstein, Leon G , McIntyre, Kim M , Knott, Anne , Dewhurst, Stephen , Insel, Richard A , Hall, Caroline Breese , Schnabel, Kenneth C , Costanzo, Maria A

1994

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Human Herpesvirus-6 Infection in Children -- A Prospective Study of Complications and Reactivation

by Caserta, Mary T , Long, Christine E , Epstein, Leon G , McIntyre, Kim M , Knott, Anne , Dewhurst, Stephen , Insel, Richard A , Hall, Caroline Breese , Schnabel, Kenneth C , Costanzo, Maria A

1994

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Journal Article

Human Herpesvirus-6 Infection in Children -- A Prospective Study of Complications and Reactivation

Caserta, Mary T,

Long, Christine E,

Epstein, Leon G,

McIntyre, Kim M,

Knott, Anne,

Dewhurst, Stephen,

Insel, Richard A,

Hall, Caroline Breese,

Schnabel, Kenneth C,

Costanzo, Maria A

1994

Overview

In follow-up studies over a period of one to two years, the HHV-6 genome persisted in blood mononuclear cells after primary infection in 37 of 56 children (66 percent). Reactivation, sometimes with febrile illnesses, was suggested by subsequent increases in antibody titers in 16 percent (30 of 187) and by PCR in 6 percent (17 of 278). No recurrent viremia was detected. Of 41 healthy newborns studied, 12 (29 percent) had the HHV-6 genome in their blood mononuclear cells; nevertheless, 6 of these newborns subsequently had primary HHV-6 infections. Conclusions: In infants and young children HHV-6 infection is a major . . .

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Publisher

Massachusetts Medical Society

Subject

Acute Disease

/ Age

/ Antibodies, Viral - biosynthesis