Journal Article

Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets

Gomes, Nelson G. M., Pereira, David M., Valentão, Patrícia, Kornienko, Alexander, Andrade, Paula B., Evdokimov, Nikolai M., Pereira, Renato B., Lefranc, Florence

2019

Overview

The role of the marine environment in the development of anticancer drugs has been widely reviewed, particularly in recent years. However, the innovation in terms of clinical benefits has not been duly emphasized, although there are important breakthroughs associated with the use of marine-derived anticancer agents that have altered the current paradigm in chemotherapy. In addition, the discovery and development of marine drugs has been extremely rewarding with significant scientific gains, such as the discovery of new anticancer mechanisms of action as well as novel molecular targets. Approximately 50 years since the approval of cytarabine, the marine-derived anticancer pharmaceutical pipeline includes four approved drugs and eighteen agents in clinical trials, six of which are in late development. Thus, the dynamic pharmaceutical pipeline consisting of approved and developmental marine-derived anticancer agents offers new hopes and new tools in the treatment of patients afflicted with previously intractable types of cancer.

• Publisher: MDPI AG,MDPI
• Subject: antibody–drug conjugates / Anticancer properties / antineoplastic agents / Antineoplastic Agents - chemistry / Antineoplastic Agents - therapeutic use / Antitumor agents / Aquatic Organisms - chemistry / Biochemistry / brentuximab vedotin / Cancer therapies / Carnitine / Chemistry / Chemotherapy / Clinical trials / Cytarabine / Drug Delivery Systems / Drug development / Drug Discovery - trends / drug therapy / Drugs / eribulin / FDA approval / Humans / Immunotherapy / Innovation / Leukemia / Licenses / lurbinectedin / Marine environment / marizomib / mechanism of action / Medical research / Meningitis / Metastasis / Monoclonal antibodies / Natural products / neoplasms / Neoplasms - drug therapy / patients / Pharmaceuticals / plinabulin / plitidepsin / plocabulin / Reagents / Response rates / Review / Submarine pipelines / Targeted cancer therapy / trabectedin / Tumors