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The effect of vitamin D supplements on the severity of restless legs syndrome
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The effect of vitamin D supplements on the severity of restless legs syndrome
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Journal Article
The effect of vitamin D supplements on the severity of restless legs syndrome
2015
Overview
Purpose
Clinical observation hinted improved symptoms of restless legs syndrome (RLS) after vitamin D supplements. Hence, the aim of this study is to evaluate the effect of vitamin D supplementation on the severity of RLS symptoms.
Methods
Twelve adult subjects diagnosed with primary RLS and vitamin D deficiency were recruited. Patients with secondary RLS were excluded from this study. The complete cell count; serum levels of ferritin, iron, glycated hemoglobin, and vitamin D3 (25 (OH) vitamin D); and renal and bone profiles of the patients were assayed. Patients with vitamin D deficiency (<50 nmol/l) were treated with vitamin D3 supplements (high oral dose or intramuscular injection). The severity scores of RLS were reassessed after the vitamin D3 level was corrected to >50 nmol/l and compared with those before the administration of the supplements.
Results
The median pretreatment vitamin D level was 21.7 nmol/l (13.45–57.4), which improved to 61.8 nmol/l (42.58–95.9) (
P
= 0.002) with the treatment. The median RLS severity score improved significantly from 26 (15–35) at baseline to 10 (0–27) after correction of the vitamin D levels (
P
= 0.002).
Conclusion
This study indicates that vitamin D supplementation improves the severity of RLS symptoms and advocates that vitamin D deficiency is conceivably associated with RLS.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Adult
/ Aged
/ Bones
/ Cholecalciferol - administration & dosage
/ Cholecalciferol - deficiency
/ Dose-Response Relationship, Drug
/ Female
/ Ferritin
/ Humans
/ Legs
/ Male
/ Medicine
/ Patients
/ Pneumology/Respiratory System
/ Restless Legs Syndrome - diagnosis
/ Restless Legs Syndrome - drug therapy
/ Restless Legs Syndrome - etiology
/ Serum
/ Severity
/ Vitamin D Deficiency - blood
/ Vitamin D Deficiency - complications
/ Vitamin D Deficiency - diagnosis
/ Vitamin D Deficiency - drug therapy
/ Vitamins
