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Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children
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Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children
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Journal Article
Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children
2019
Overview
Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of
Propionibacterium
phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of
Propionibacterium
phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and
Propionibacterium
phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time.
Here, the authors determine the respiratory virome and serum cytokine profile in children diagnosed with acute respiratory tract infections (ARTI) and show that relative abundance of
Propionibacterium
phages as well as serum levels of TIMP-1 and PDGF-BB are increased in multiple ARTIs compared with single ARTI.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/22
/ 45/23
/ 45/88
/ 49/90
/ 82/79
/ Bacteriophages - isolation & purification
/ Child
/ Children
/ Disease Susceptibility - blood
/ Disease Susceptibility - immunology
/ Disease Susceptibility - microbiology
/ Female
/ High-Throughput Nucleotide Sequencing - methods
/ Humanities and Social Sciences
/ Humans
/ Infant
/ Male
/ Phages
/ Platelet-derived growth factor
/ Platelet-derived growth factor BB
/ Propionibacterium - virology
/ Respiratory System - immunology
/ Respiratory System - virology
/ Respiratory Tract Infections - blood
/ Respiratory Tract Infections - immunology
/ Respiratory Tract Infections - microbiology
/ Science
