Asset Details
Do you wish to reserve the book?
Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
Do you wish to request the book?
Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
2021
Overview
Neuroinflammation is associated with Alzheimer’s disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins related to microglial and T-cell functions, and show them to reproducibly form functionally-related groups within and across diagnostic categories in 382 participants from the Alzheimer’s Disease Neuro-imaging Initiative as well participants from two independent cohorts. We further show higher levels of proteins related to soluble tumor necrosis factor receptor 1 are associated with reduced risk of conversion to dementia in the multi-centered (
p
= 0.027) and independent (
p
= 0.038) cohorts of people with mild cognitive impairment due to predicted Alzheimer’s disease, while higher soluble TREM2 levels associated with slower decline in the dementia stage of Alzheimer’s disease. These inflammatory proteins thus provide prognostic information independent of established Alzheimer’s markers.
Neuroinflammation is observed in Alzheimer’s disease. Here the authors show that 15 proteins related to inflammation found in CSF can potentially be used as a prognostic biomarker.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 82/79
/ Aged
/ Alzheimer Disease - cerebrospinal fluid
/ Alzheimer Disease - pathology
/ Amyloid beta-Peptides - cerebrospinal fluid
/ Biomarkers - cerebrospinal fluid
/ Cerebrospinal Fluid Proteins - analysis
/ Cognitive Dysfunction - pathology
/ Dementia
/ Female
/ Humanities and Social Sciences
/ Humans
/ Male
/ Membrane Glycoproteins - cerebrospinal fluid
/ Peptide Fragments - cerebrospinal fluid
/ Proteins
/ Receptors, Tumor Necrosis Factor, Type I - cerebrospinal fluid
/ Science
