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Tissue alkalosis in cold-ischemia time

by Carraro, D. M. , Uceda, A. , Suenaga, A. P. , Soares, F. A. , Denninghoff, V. , Campos, A. H. J. Fróes Marques , Olivieri, E. H. R. , Avagnina, A. , Martins, V. R. , Fresno, C. , Mota, L.

in 38 / 38/23 / 38/39 / 38/61 / 38/71 / 38/77 / 631/1647/2017/2079 / 692/308/575 / Alkalosis / Biological stress / Gene expression / Humanities and Social Sciences / Ischemia / Kidneys / Liver / multidisciplinary / Organ removal / pH effects / Science / Science (multidisciplinary) / Tissues

2017

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Tissue alkalosis in cold-ischemia time

by Carraro, D. M. , Uceda, A. , Suenaga, A. P. , Soares, F. A. , Denninghoff, V. , Campos, A. H. J. Fróes Marques , Olivieri, E. H. R. , Avagnina, A. , Martins, V. R. , Fresno, C. , Mota, L.

2017

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Tissue alkalosis in cold-ischemia time

by Carraro, D. M. , Uceda, A. , Suenaga, A. P. , Soares, F. A. , Denninghoff, V. , Campos, A. H. J. Fróes Marques , Olivieri, E. H. R. , Avagnina, A. , Martins, V. R. , Fresno, C. , Mota, L.

2017

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Journal Article

Tissue alkalosis in cold-ischemia time

Carraro, D. M.,

Uceda, A.,

Suenaga, A. P.,

Soares, F. A.,

Denninghoff, V.,

Campos, A. H. J. Fróes Marques,

Olivieri, E. H. R.,

Avagnina, A.,

Martins, V. R.,

Fresno, C.,

Mota, L.

2017

Overview

The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polynomial model) in mice for liver, kidney and lung samples. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Therefore, tissue-pH regulation after organ removal may minimize biological stress in human tissue samples.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ 38/23

/ 38/39

/ 38/61

/ 38/71

/ 38/77

/ 631/1647/2017/2079

/ 692/308/575