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Parasitic insect-derived miRNAs modulate host development
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Journal Article
Parasitic insect-derived miRNAs modulate host development
2018
Overview
Parasitic wasps produce several factors including venom, polydnaviruses (PDVs) and specialized wasp cells named teratocytes that benefit the survival of offspring by altering the physiology of hosts. However, the underlying molecular mechanisms for the alterations remain unclear. Here we find that the teratocytes of
Cotesia vestalis
, an endoparasitoid of the diamondback moth
Plutella xylostella
, and its associated bracovirus (CvBV) can produce miRNAs and deliver the products into the host via different ways. Certain miRNAs in the parasitized host are mainly produced by teratocytes, while the expression level of miRNAs encoded by CvBV can be 100-fold greater in parasitized hosts than non-parasitized ones. We further show that one teratocyte-produced miRNA (Cve-miR-281-3p) and one CvBV-produced miRNA (Cve-miR-novel22-5p-1) arrest host growth by modulating expression of the host ecdysone receptor (
EcR
). Altogether, our results show the first evidence of cross-species regulation by miRNAs in animal parasitism and their possible function in the alteration of host physiology during parasitism.
The moth
Plutella xylostella
during its larval stage is the host of the endoparasitic wasp
Cotesia vestalis
. Here the authors show that the parasitoids deliver microRNAs to their hosts through their symbiotic virus and specialized cells leading to induced developmental delay.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/34
/ 38/39
/ 45/41
/ 45/77
/ 45/91
/ 82/80
/ Animals
/ Coding
/ Ecdysone
/ Female
/ Gene Expression Regulation, Developmental - genetics
/ Host-Parasite Interactions - genetics
/ Humanities and Social Sciences
/ miRNA
/ Moths - growth & development
/ Receptors, Steroid - genetics
/ Receptors, Steroid - metabolism
/ Science
/ Venom
