Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients

by Alali, Rudaynah A. , Alshakhs, Marai N. , Almulaify, Mohammed S. , Alsaad, Hassan A. , Alturaifi, Hussain , Alaswad, Ahmed , Abohelaika, Salah , AlSheikh, Mona H. , Alhaddad, Mousa J. , Bidasee, Sean R. , Almarzouk, Hassan M. , Almualim, Mohammed , Alomar, Fadhel A. , Alessa, Faisal S. , Alsalman, Abdulkhaliq J. , Al Mohaini, Mohammed , Alomar, Mohammed F. , Al-Muhanna, Fahad , Bidasee, Keshore R. , Al-Ali, Amein K. , Akhtar, Mohammed S. , Alsalman, Ahmed S.

in 631/326/596/4130 / 631/80/304 / 692/53/2423 / Biomarkers / Coronaviruses / COVID-19 / Glutathione / Glycolysis / Humanities and Social Sciences / IL-1β / Monocytes / Mortality / Mortality risk / multidisciplinary / Plasma levels / Pyruvaldehyde / Regression analysis / Science / Science (multidisciplinary) / Tumor necrosis factor-α

2022

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients

2022

Confirm

Do you wish to request the book?

Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients

2022

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients

Alali, Rudaynah A.,

Alshakhs, Marai N.,

Almulaify, Mohammed S.,

Alsaad, Hassan A.,

Alturaifi, Hussain,

Alaswad, Ahmed,

Abohelaika, Salah,

AlSheikh, Mona H.,

Alhaddad, Mousa J.,

Bidasee, Sean R.,

Almarzouk, Hassan M.,

Almualim, Mohammed,

Alomar, Fadhel A.,

Alessa, Faisal S.,

Alsalman, Abdulkhaliq J.,

Al Mohaini, Mohammed,

Alomar, Mohammed F.,

Al-Muhanna, Fahad,

Bidasee, Keshore R.,

Al-Ali, Amein K.,

Akhtar, Mohammed S.,

Alsalman, Ahmed S.

2022

Overview

Biomarkers to identify ICU COVID-19 patients at high risk for mortality are urgently needed for therapeutic care and management. Here we found plasma levels of the glycolysis byproduct methylglyoxal (MG) were 4.4-fold higher in ICU patients upon admission that later died (n = 33), and 1.7-fold higher in ICU patients that survived (n = 32),compared to uninfected controls (n = 30). The increased MG in patients that died correlated inversely with the levels of the MG-degrading enzyme glyoxalase-1 ( r 2 = − 0.50), and its co-factor glutathione ( r 2 = − 0.63), and positively with monocytes ( r 2 = 0.29). The inflammation markers, SSAO ( r 2 = 0.52), TNF-α ( r 2 = 0.41), IL-1β ( r 2 = 0.25), CRP ( r 2 = 0.26) also correlated positively with MG. Logistic regression analysis provides evidence of a significant relationship between the elevated MG upon admission into ICU and death (P < 0.0001), with 42% of the death variability explained. From these data we conclude that elevated plasma MG on admission is a novel independent biomarker that predicts mortality in ICU COVID-19 patients.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject