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Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae
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Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae
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Journal Article
Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae
2021
Overview
Many toxic secondary metabolites produced by phytopathogens can subvert host immunity, and some of them are recognized as pathogenicity factors. Fusarium head blight and Verticillium wilt are destructive plant diseases worldwide. Using toxins produced by the causal fungi
Fusarium graminearum
and
Verticillium dahliae
as screening agents, here we show that the
Arabidopsis
P4 ATPases AtALA1 and AtALA7 are responsible for cellular detoxification of mycotoxins. Through AtALA1-/AtALA7-mediated vesicle transport, toxins are sequestered in vacuoles for degradation. Overexpression of
AtALA1
and
AtALA7
significantly increases the resistance of transgenic plants to
F. graminearum
and
V. dahliae
, respectively. Notably, the concentration of deoxynivalenol, a mycotoxin harmful to the health of humans and animals, was decreased in transgenic
Arabidopsis
siliques and maize seeds. This vesicle-mediated cell detoxification process provides a strategy to increase plant resistance against different toxin-associated diseases and to reduce the mycotoxin contamination in food and feed.
Toxic metabolites produced by phytopathogens can subvert host immunity. Here the authors show that the
Arabidopsis
P4-ATPases, AtALA1 and AtALA7 mediate mycotoxin detoxification by promoting vesicle transport and their subsequent sequestration and degradation in vacuoles.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
