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Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae
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Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae
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Journal Article
Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae
2019
Overview
Biofilm formation protects bacteria from stresses including antibiotics and host immune responses. Carbon sources can modulate biofilm formation and host colonization in
Vibrio cholerae
, but the underlying mechanisms remain unclear. Here, we show that EIIA
Glc
, a component of the phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS), regulates the intracellular concentration of the cyclic dinucleotide c-di-GMP, and thus biofilm formation. The availability of preferred sugars such as glucose affects EIIA
Glc
phosphorylation state, which in turn modulates the interaction of EIIA
Glc
with a c-di-GMP phosphodiesterase (hereafter referred to as PdeS). In a
Drosophila
model of
V. cholerae
infection, sugars in the host diet regulate gut colonization in a manner dependent on the PdeS-EIIA
Glc
interaction. Our results shed light into the mechanisms by which some nutrients regulate biofilm formation and host colonization.
Carbon sources can modulate biofilm formation and host colonization in
Vibrio cholerae
. Here, Heo et al. show that this process is mediated by a component of the PEP:carbohydrate phosphotransferase system (PTS), which regulates c-di-GMP hydrolysis by interacting with a c-di-GMP phosphodiesterase.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/35
/ 3',5'-Cyclic-GMP Phosphodiesterases - genetics
/ 3',5'-Cyclic-GMP Phosphodiesterases - metabolism
/ 38/88
/ 631/45
/ 64/24
/ 82/29
/ 82/83
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Biofilms
/ Biofilms - growth & development
/ Cyclic GMP - analogs & derivatives
/ Gene Expression Regulation, Bacterial
/ Humanities and Social Sciences
/ Phosphoenolpyruvate Sugar Phosphotransferase System - genetics
/ Phosphoenolpyruvate Sugar Phosphotransferase System - metabolism
/ Science
/ Sugar
/ Vibrio cholerae - enzymology
