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Multi-centre discriminating concentration determination of broflanilide and potential for cross-resistance to other public health insecticides in Anopheles vector populations
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Multi-centre discriminating concentration determination of broflanilide and potential for cross-resistance to other public health insecticides in Anopheles vector populations
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Journal Article
Multi-centre discriminating concentration determination of broflanilide and potential for cross-resistance to other public health insecticides in Anopheles vector populations
2022
Overview
Novel insecticides are urgently needed to control insecticide-resistant populations of
Anopheles
malaria vectors. Broflanilide acts as a non-competitive antagonist of the gamma-aminobutyric acid receptor and has shown prolonged effectiveness as an indoor residual spraying product (VECTRON T500) in experimental hut trials against pyrethroid-resistant vector populations. This multi-centre study expanded upon initial discriminating concentration testing of broflanilide, using six
Anopheles
insectary colonies (
An. gambiae
Kisumu KCMUCo,
An. gambiae
Kisumu NIMR,
An. arabiensis
KGB,
An. arabiensis
SENN,
An. coluzzii
N’Gousso and
An. stephensi
SK), representing major malaria vector species, to facilitate prospective susceptibility monitoring of this new insecticide; and investigated the potential for cross-resistance to broflanilide via the A296S mutation associated with dieldrin resistance (
rdl
). Across all vector species tested, the discriminating concentration for broflanilide ranged between LC
99
× 2 = 1.126–54.00 μg/ml or LC
95
× 3 = 0.7437–17.82 μg/ml. Lower concentrations of broflanilide were required to induce complete mortality of
An. arabiensis
SENN (dieldrin-resistant), compared to its susceptible counterpart,
An. arabiensis
KGB, and there was no association between the presence of the
rdl
mechanism of resistance and survival in broflanilide bioassays, demonstrating a lack of cross-resistance to broflanilide. Study findings provide a benchmark for broflanilide susceptibility monitoring as part of ongoing VECTRON T500 community trials in Tanzania and Benin.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
