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Small RNA pathways in the nematode Ascaris in the absence of piRNAs
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Small RNA pathways in the nematode Ascaris in the absence of piRNAs
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Journal Article
Small RNA pathways in the nematode Ascaris in the absence of piRNAs
2022
Overview
Small RNA pathways play key and diverse regulatory roles in
C. elegans
, but our understanding of their conservation and contributions in other nematodes is limited. We analyzed small RNA pathways in the divergent parasitic nematode
Ascaris. Ascaris
has ten Argonautes with five worm-specific Argonautes (WAGOs) that associate with secondary 5’-triphosphate 22-24G-RNAs. These small RNAs target repetitive sequences or mature mRNAs and are similar to the
C. elegans
mutator, nuclear, and CSR-1 small RNA pathways. Even in the absence of a piRNA pathway,
Ascaris
CSR-1 may still function to “license” as well as fine-tune or repress gene expression.
Ascaris
ALG-4 and its associated 26G-RNAs target and likely repress specific mRNAs during testis meiosis.
Ascaris
WAGO small RNAs demonstrate target plasticity changing their targets between repeats and mRNAs during development. We provide a unique and comprehensive view of mRNA and small RNA expression throughout spermatogenesis. Overall, our study illustrates the conservation, divergence, dynamics, and flexibility of small RNA pathways in nematodes.
The parasitic nematode
Ascaris
lacks piRNAs. Here the authors compare Argonaute proteins and small RNAs from
C. elegans
and
Ascaris
, expanding our understanding of the conservation, divergence, and flexibility of Argonautes and small RNA pathways in nematodes.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/90
/ 38/91
/ Animals
/ Argonaute Proteins - metabolism
/ Ascaris
/ Caenorhabditis elegans - genetics
/ Caenorhabditis elegans Proteins - metabolism
/ Gene Expression Regulation, Developmental
/ Humanities and Social Sciences
/ Meiosis
/ RNA
/ RNA, Small Interfering - metabolism
/ Science
/ Worms
