Asset Details
Do you wish to reserve the book?
The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans
Do you wish to request the book?
The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans
2019
Overview
β-Mannans are plant cell wall polysaccharides that are commonly found in human diets. However, a mechanistic understanding into the key populations that degrade this glycan is absent, especially for the dominant Firmicutes phylum. Here, we show that the prominent butyrate-producing Firmicute
Roseburia intestinalis
expresses two loci conferring metabolism of β-mannans. We combine multi-“omic” analyses and detailed biochemical studies to comprehensively characterize loci-encoded proteins that are involved in β-mannan capturing, importation, de-branching and degradation into monosaccharides. In mixed cultures,
R. intestinalis
shares the available β-mannan with
Bacteroides ovatus
, demonstrating that the apparatus allows coexistence in a competitive environment. In murine experiments, β-mannan selectively promotes beneficial gut bacteria, exemplified by increased
R. intestinalis
, and reduction of mucus-degraders. Our findings highlight that
R. intestinalis
is a primary degrader of this dietary fiber and that this metabolic capacity could be exploited to selectively promote key members of the healthy microbiota using β-mannan-based therapeutic interventions.
How dietary β-mannans are utilized by gut Gram-positive bacteria is unclear. Here, the authors uncover the enzymatic pathway for β-mannan metabolism in
Roseburia intestinalis
and show that these polysaccharides promote beneficial gut bacteria, highlighting a potential for β-mannan-based therapeutic interventions.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
