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Structural brain abnormalities and their association with language impairment in school-aged children with Autism Spectrum Disorder
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Structural brain abnormalities and their association with language impairment in school-aged children with Autism Spectrum Disorder
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Journal Article
Structural brain abnormalities and their association with language impairment in school-aged children with Autism Spectrum Disorder
2023
Overview
Language impairment is comorbid in most children with Autism Spectrum Disorder (ASD) but its neural basis is poorly understood. Using structural magnetic resonance imaging (MRI), the present study provides the whole-brain comparison of both volume- and surface-based characteristics between groups of children with and without ASD and investigates the relationships between these characteristics in language-related areas and the language abilities of children with ASD measured with standardized tools. A total of 36 school-aged children participated in the study: 18 children with ASD and 18 age- and sex-matched typically developing controls. The results revealed that multiple regions differed between groups of children in gray matter volume, gray matter thickness, gyrification, and cortical complexity (fractal dimension). White matter volume and sulcus depth did not differ between groups of children in any region. Importantly, gray matter thickness and gyrification of language-related areas were related to language functioning in children with ASD. Thus, the results of the present study shed some light on the structural brain abnormalities associated with language impairment in ASD.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Autism
/ Autism Spectrum Disorder - complications
/ Autism Spectrum Disorder - diagnostic imaging
/ Autism Spectrum Disorder - pathology
/ Cerebral Cortex - diagnostic imaging
/ Child
/ Children
/ Humanities and Social Sciences
/ Humans
/ Language
/ Language Development Disorders - complications
/ Language Development Disorders - epidemiology
/ Language Development Disorders - pathology
/ Magnetic Resonance Imaging - methods
/ Science
