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Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate
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Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate
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Journal Article
Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate
2022
Overview
The gut microbiota has been linked to many cancers, yet its role in acute myeloid leukaemia (AML) progression remains unclear. Here, we show decreased diversity in the gut microbiota of AML patients or murine models. Gut microbiota dysbiosis induced by antibiotic treatment accelerates murine AML progression while faecal microbiota transplantation reverses this process. Butyrate produced by the gut microbiota (especially
Faecalibacterium
) significantly decreases in faeces of AML patients, while gavage with butyrate or
Faecalibacterium
postpones murine AML progression. Furthermore, we find the intestinal barrier is damaged in mice with AML, which accelerates lipopolysaccharide (LPS) leakage into the blood. The increased LPS exacerbates leukaemia progression in vitro and in vivo. Butyrate can repair intestinal barrier damage and inhibit LPS absorption in AML mice. Collectively, we demonstrate that the gut microbiota promotes AML progression in a metabolite-dependent manner and that targeting the gut microbiota might provide a therapeutic option for AML.
The role of gut microbiota in acute myeloid leukaemia (AML) remains unclear. Here, the authors show disordered gut microbiota and reduced butyrate cause intestinal barrier damage in AML mice, with increased plasma LPS that accelerates AML progression.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
