Asset Details
Do you wish to reserve the book?
FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
Do you wish to request the book?
FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
2020
Overview
Regulation of the programming of tumour-associated macrophages (TAMs) controls tumour growth and anti-tumour immunity. We examined the role of FGF2 in that regulation. Tumours in mice genetically deficient in low-molecular weight FGF2 (FGF2
LMW
) regress dependent on T cells. Yet, TAMS not T cells express FGF receptors. Bone marrow derived-macrophages from
Fgf2
LMW−/−
mice co-injected with cancer cells reduce tumour growth and express more inflammatory cytokines. FGF2 is induced in the tumour microenvironment following fractionated radiation in murine tumours consistent with clinical reports. Combination treatment of in vivo tumours with fractionated radiation and a blocking antibody to FGF2 prolongs tumour growth delay, increases long-term survival and leads to a higher iNOS
+
/CD206
+
TAM ratio compared to irradiation alone. These studies show for the first time that FGF2 affects macrophage programming and is a critical regulator of immunity in the tumour microenvironment.
Macrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. As a result, disruption of this macrophage programming by anti-FGF2 blocking antibodies enhances the outcome from radiotherapy.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/1
/ 13/106
/ 13/21
/ 13/51
/ Animals
/ Fibroblast Growth Factor 2 - genetics
/ Fibroblast Growth Factor 2 - metabolism
/ Humanities and Social Sciences
/ Humans
/ Immunity
/ Lectins, C-Type - metabolism
/ Macrophage Activation - drug effects
/ Macrophage Activation - radiation effects
/ Mannose-Binding Lectins - genetics
/ Mannose-Binding Lectins - metabolism
/ Mice
/ Nitric Oxide Synthase Type II - genetics
/ Nitric Oxide Synthase Type II - metabolism
/ Receptors, Cell Surface - genetics
/ Receptors, Cell Surface - metabolism
/ Science
/ Tumor Microenvironment - drug effects
/ Tumor Microenvironment - radiation effects
/ Tumors
