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PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis
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PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis
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Journal Article
PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis
2022
Overview
Here, in
Ppara
−/−
mice, we found that an increased DNL stimulated the cartilage degradation and identified ACOT12 as a key regulatory factor. Suppressed level of ACOT12 was observed in cartilages of OA patient and OA-induced animal. To determine the role and association of ACOT12 in the OA pathogenesis, we generated
Acot12
knockout (KO) (
Acot12
−/−
) mice using RNA-guided endonuclease.
Acot12
−/−
mice displayed the severe cartilage degradation with the stimulation of matrix MMPs and chondrocyte apoptosis through the accumulation of acetyl CoA. Delivery of acetyl CoA-conjugated chitosan complex into cartilage stimulated DNL and cartilage degradation. Moreover, restoration of ACOT12 into human OA chondrocytes and OA-induced mouse cartilage effectively rescued the pathophysiological features of OA by regulating DNL. Taken together, our study suggested ACOT12 as a novel regulatory factor in maintaining cartilage homeostasis and targeting ACOT12 could contribute to developing a new therapeutic strategy for OA.
Increasing evidence suggested that dysregulation in lipid metabolism is linked to OA pathogenesis, but the underlying regulatory mechanism is not well understood. Here, the authors show that PPARα-ACOT12 signalling regulates cartilage homeostasis by regulating de novo lipogenesis in mice.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
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/ 13/51
/ 13/89
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/ 14/28
/ 38/61
/ 38/88
/ 38/90
/ 38/91
/ 42/34
/ 64/60
/ 82/51
/ 82/80
/ 96/95
/ Acetyl Coenzyme A - metabolism
/ Animals
/ Cartilage, Articular - metabolism
/ Chitosan
/ Humanities and Social Sciences
/ Humans
/ Lipids
/ Matrix Metalloproteinases - metabolism
/ Mice
/ Regulatory mechanisms (biology)
/ Science
