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Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes
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Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes
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Journal Article
Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes
2020
Overview
Flaviviruses, including Zika virus (ZIKV), utilise host mRNA degradation machinery to produce subgenomic flaviviral RNA (sfRNA). In mammalian hosts, this noncoding RNA facilitates replication and pathogenesis of flaviviruses by inhibiting IFN-signalling, whereas the function of sfRNA in mosquitoes remains largely elusive. Herein, we conduct a series of in vitro and in vivo experiments to define the role of ZIKV sfRNA in infected
Aedes aegypti
employing viruses deficient in production of sfRNA. We show that sfRNA-deficient viruses have reduced ability to disseminate and reach saliva, thus implicating the role for sfRNA in productive infection and transmission. We also demonstrate that production of sfRNA alters the expression of mosquito genes related to cell death pathways, and prevents apoptosis in mosquito tissues. Inhibition of apoptosis restored replication and transmission of sfRNA-deficient mutants. Hence, we propose anti-apoptotic activity of sfRNA as the mechanism defining its role in ZIKV transmission.
The function on subgenomic flaviviral RNA (sfRNA) in the mosquito vector is not well understood. Here, Slonchak et al. show that sfRNA affects virus-induced apoptosis and dissemination of ZIKV in
Aedes aegypti
mosquitoes, suggesting a role of sfRNA in Zika virus replication and transmission.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 14/19
/ 38/39
/ 38/70
/ 38/77
/ 38/88
/ 38/90
/ 38/91
/ Animals
/ Humanities and Social Sciences
/ Humans
/ Insect Proteins - metabolism
/ mRNA
/ RNA
/ RNA, Untranslated - genetics
/ RNA, Untranslated - metabolism
/ Saliva
/ Science
/ Virus Replication - genetics
/ Viruses
/ Zika Virus Infection - genetics
