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Oral and ocular late effects in head and neck cancer patients treated with radiotherapy
by
Jensen, Janicke Liaaen
, Herlofson, Bente Brokstad
, Amdal, Cecilie Delphin
, Chen, Xiangjun
, Rykke, Morten
, Utheim, Tor P.
, Hove, Lene Hystad
, Singh, Preet Bano
, Aqrawi, Lara A.
, Hynne, Håvard
, Young, Alix
, Westgaard, Kristine Løken
in
692/699/3017
/ 692/699/3020
/ 692/699/3020/3031
/ 692/699/3161
/ 692/699/67/1536
/ 692/700/784
/ Aged
/ Dry Eye Syndromes
/ Eye
/ Eye diseases
/ Eye Diseases - etiology
/ Female
/ Head & neck cancer
/ Head and Neck Neoplasms - radiotherapy
/ Humanities and Social Sciences
/ Humans
/ Male
/ Middle Aged
/ multidisciplinary
/ Norway
/ Oral hygiene
/ Quality of Life
/ Radiation therapy
/ Radiotherapy - adverse effects
/ Radiotherapy, Intensity-Modulated - adverse effects
/ Radiotherapy, Intensity-Modulated - methods
/ Saliva
/ Saliva - chemistry
/ Salivary Gland Diseases - etiology
/ Salivation
/ Science
/ Science (multidisciplinary)
/ Stomatognathic Diseases - etiology
/ Surveys and Questionnaires
/ Xerostomia
2021
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Oral and ocular late effects in head and neck cancer patients treated with radiotherapy
by
Jensen, Janicke Liaaen
, Herlofson, Bente Brokstad
, Amdal, Cecilie Delphin
, Chen, Xiangjun
, Rykke, Morten
, Utheim, Tor P.
, Hove, Lene Hystad
, Singh, Preet Bano
, Aqrawi, Lara A.
, Hynne, Håvard
, Young, Alix
, Westgaard, Kristine Løken
in
692/699/3017
/ 692/699/3020
/ 692/699/3020/3031
/ 692/699/3161
/ 692/699/67/1536
/ 692/700/784
/ Aged
/ Dry Eye Syndromes
/ Eye
/ Eye diseases
/ Eye Diseases - etiology
/ Female
/ Head & neck cancer
/ Head and Neck Neoplasms - radiotherapy
/ Humanities and Social Sciences
/ Humans
/ Male
/ Middle Aged
/ multidisciplinary
/ Norway
/ Oral hygiene
/ Quality of Life
/ Radiation therapy
/ Radiotherapy - adverse effects
/ Radiotherapy, Intensity-Modulated - adverse effects
/ Radiotherapy, Intensity-Modulated - methods
/ Saliva
/ Saliva - chemistry
/ Salivary Gland Diseases - etiology
/ Salivation
/ Science
/ Science (multidisciplinary)
/ Stomatognathic Diseases - etiology
/ Surveys and Questionnaires
/ Xerostomia
2021
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Oral and ocular late effects in head and neck cancer patients treated with radiotherapy
by
Jensen, Janicke Liaaen
, Herlofson, Bente Brokstad
, Amdal, Cecilie Delphin
, Chen, Xiangjun
, Rykke, Morten
, Utheim, Tor P.
, Hove, Lene Hystad
, Singh, Preet Bano
, Aqrawi, Lara A.
, Hynne, Håvard
, Young, Alix
, Westgaard, Kristine Løken
in
692/699/3017
/ 692/699/3020
/ 692/699/3020/3031
/ 692/699/3161
/ 692/699/67/1536
/ 692/700/784
/ Aged
/ Dry Eye Syndromes
/ Eye
/ Eye diseases
/ Eye Diseases - etiology
/ Female
/ Head & neck cancer
/ Head and Neck Neoplasms - radiotherapy
/ Humanities and Social Sciences
/ Humans
/ Male
/ Middle Aged
/ multidisciplinary
/ Norway
/ Oral hygiene
/ Quality of Life
/ Radiation therapy
/ Radiotherapy - adverse effects
/ Radiotherapy, Intensity-Modulated - adverse effects
/ Radiotherapy, Intensity-Modulated - methods
/ Saliva
/ Saliva - chemistry
/ Salivary Gland Diseases - etiology
/ Salivation
/ Science
/ Science (multidisciplinary)
/ Stomatognathic Diseases - etiology
/ Surveys and Questionnaires
/ Xerostomia
2021
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Oral and ocular late effects in head and neck cancer patients treated with radiotherapy
Journal Article
Oral and ocular late effects in head and neck cancer patients treated with radiotherapy
2021
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Overview
A broader understanding of oral and ocular late effects in head and neck cancer (HNC) patients who underwent intensity-modulated radiotherapy (IMRT) may provide valuable information in follow-up and improve quality of life. Twenty-nine HNC patients treated at least 6 months earlier and 30 age-matched controls were recruited. After completing several questionnaires: Oral Health Impact Profile-14 (OHIP-14), Shortened Xerostomia Inventory (SXI), Ocular Surface Disease Index (OSDI) and McMonnies Dry Eye questionnaire (MDEQ), participants underwent oral and ocular examinations. Oral examination included clinical oral dryness score (CODS) and secretion rates of unstimulated and stimulated saliva (UWS, SWS). Ocular examination included tear film break-up time, Schirmer test and ocular surface staining. The patients had more problems related to dry mouth than controls based on CODS and SXI, and more complaints of dry eye disease based on OSDI and MDEQ. UWS and SWS rates and oral health related quality of life were significantly lower in the patient group. Subjective oral dryness (SXI) correlated significantly with subjective ocular dryness (OSDI and MDEQ). Our study demonstrates that HNC patients treated with IMRT experience late effects in terms of xerostomia and ocular dryness underlining the importance of interdisciplinary approach in the evaluation and follow-up of HNC patients.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Aged
/ Eye
/ Female
/ Head and Neck Neoplasms - radiotherapy
/ Humanities and Social Sciences
/ Humans
/ Male
/ Norway
/ Radiotherapy - adverse effects
/ Radiotherapy, Intensity-Modulated - adverse effects
/ Radiotherapy, Intensity-Modulated - methods
/ Saliva
/ Salivary Gland Diseases - etiology
/ Science
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