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Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans
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Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans
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Journal Article
Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans
2019
Overview
Cryptococcus neoformans
(
C. neoformans
var.
grubii
) is an environmentally acquired pathogen causing 181,000 HIV-associated deaths each year. We sequenced 699 isolates, primarily
C. neoformans
from HIV-infected patients, from 5 countries in Asia and Africa. The phylogeny of
C. neoformans
reveals a recent exponential population expansion, consistent with the increase in the number of susceptible hosts. In our study population, this expansion has been driven by three sub-clades of the
C. neoformans
VNIa lineage; VNIa-4, VNIa-5 and VNIa-93. These three sub-clades account for 91% of clinical isolates sequenced in our study. Combining the genome data with clinical information, we find that the VNIa-93 sub-clade, the most common sub-clade in Uganda and Malawi, was associated with better outcomes than VNIa-4 and VNIa-5, which predominate in Southeast Asia. This study lays the foundation for further work investigating the dominance of VNIa-4, VNIa-5 and VNIa-93 and the association between lineage and clinical phenotype.
Cryptococcus neoformans
is an opportunistic fungal pathogen which primarily affects people with immune defects including those living with HIV. Here, the authors sequence and analyze genomes of 699 isolates, and identify recent population expansion driven by three phylogenetic groups.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/23
/ AIDS-Related Opportunistic Infections - epidemiology
/ AIDS-Related Opportunistic Infections - microbiology
/ Antifungal Agents - therapeutic use
/ Cryptococcosis - epidemiology
/ Cryptococcosis - microbiology
/ Cryptococcus neoformans - genetics
/ Cryptococcus neoformans - isolation & purification
/ Cryptococcus neoformans - pathogenicity
/ Disease
/ Fungi
/ Genomes
/ HIV
/ Human immunodeficiency virus
/ Humanities and Social Sciences
/ Humans
/ Medicine
/ Science
